Lipid Membrane Structure and Behavior

This paper shows that VBIT-4 disrupts mitochondrial membranes and causes cytotoxicity, challenging its role as a VDAC1 oligomerization inhibitor.

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

This study uses simulations to show that groove architecture, not amino acid sequence, determines lipid scrambling in scramblase proteins.

The paper develops a cell-based phospholipid scrambling assay to show that TMEM16F preferentially scrambles phosphatidylserine and phosphatidylcholine over phosphatidylethanolamine.

This study examines how the membrane environment affects enzymatic reactions, finding that it enhances activity but imposes diffusion limitations, which can be mitigated by adjusting enzyme membrane affinity.

This study uses molecular dynamics simulations to show that plasma membrane leaflets have distinct structural and dynamic properties, with the inner leaflet forming nanoscale domains and the outer leaflet being liquid-ordered.

This study identifies RhoA's role in modulating ordered membrane domains (OMDs) under stress, linking cytoskeletal changes to membrane mechanics and neuropathic pain.

This study examines how mitochondrial outer membrane lipids affect VDAC1 assembly using atomic force microscopy and simulations, showing lipid regulation of VDAC organization.

This study uses numerical simulations and analytical theory to examine the physical requirements and biological consequences of asymmetric hop diffusion in cell membranes.

2Danalysis projects membrane and biopolymer properties to a 2D plane to analyze interactions and spatial correlations in simulations.

The paper revises the diffusion law to quantify nanoscale membrane organization parameters using STED-FCS data, validating the Saffman-Delbruck assumption for lipid diffusion.

This study investigates the membrane remodeling activities of BDLP from Nostoc punctiforme, showing it functions as a scaffold regulated by nucleotide binding rather than mediating fusion.

This paper investigates how temozolomide crosses brain plasma membranes using molecular dynamics simulations, finding that it cannot cross by pure diffusion at normal body temperature but requires higher temperatures or assistance from cholesterol and cerebroside lipids.

The paper introduces HMFF, a method integrating experimental data into membrane simulations, and applies it to various biological systems to enable multi-scale modeling.

This study combines experiments and simulations to investigate how coacervate-membrane interactions affect membrane morphology and fluidity, showing that anionic lipid content modulates these effects.

This study uses atomistic and coarse-grained MD simulations to investigate the kinetics and mechanism of phase separation in ternary lipid mixtures containing APP C99, identifying three distinct time regimes.

This study shows that TMEM16F-mediated lipid scrambling drives the formation and release of apoptotic-like vesicles without affecting cytosolic calcium or the cytoskeleton.

This study shows that Chikungunya virus nsP1 preferentially binds to positively curved membranes, enabling saddle curvature association critical for replication complex assembly.

This paper identifies three minimal lipid-only model systems that mimic the lipid composition and mechanical properties of E. coli inner membrane.

This study develops a computational model to simulate toroidal membranes and investigates their lipid properties and protein interactions during membrane fission processes.

The paper investigates the lipid phase behavior in thylakoid membrane curvature regions of spinach, revealing an isotropic non-bilayer phase enriched in monogalactosyldiacylglycerol.

The paper investigates how cardiolipin interacts with membrane proteins to stabilize them, using a model protein and simulations to identify key factors.

This study investigates how myelin proteins P0, MBP, and P2 interact with lipid membranes and each other, revealing both synergistic and competitive effects on membrane structure and stability.

This study shows that disrupting plasma membrane lipid asymmetry in mammalian cells alters cellular energetics by shifting metabolism from anabolic to catabolic states.

This study shows that lipid flip flop regulates the shape of synthetic cells during growth and division by relaxing curvature stresses and enabling symmetric bud formation and scission.

The paper introduces three new methods to quantify dynamic interdigitation in lipid bilayers using atomistic simulations, providing detailed insights into interleaflet interactions.

This study investigates how StarD4 recognizes PIP2 subtypes and how this recognition affects cholesterol transport kinetics through molecular dynamics and machine learning analysis.

This paper develops a biophysical model to show glycocalyx can induce membrane tube formation through critical grafting density and polymer length, facilitated by actin forces and line tension.

This study investigates how ApoA-I interacts with lipid membranes to induce shape remodeling and lipid phase separation in GUVs, revealing key steps in lipoprotein assembly.