Muscle Physiology and Disorders

This study identifies myofiber shape as a marker of skeletal muscle aging in humans and mice, showing that resistance training reverses shape irregularities in type II myofibers.

This study shows that loss of Mfn2 reduces MAM and activates Notch signaling in muscle atrophy, and DAPT treatment improves mitochondrial function and regeneration.

This study develops a novel imaging method (FIM-ID) to show that myofibrillogenesis, not myofibril hypertrophy, drives mechanically induced skeletal muscle growth.

The paper compares transcriptional responses to resistance exercise in rats and mice, finding conserved pathways but species-specific differences in energy metabolism.

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.

The paper describes a method to isolate skeletal muscle from mice, generate satellite cells for culture, and validate cell populations using immunofluorescence.

This study shows that cold temperatures reduce zebrafish swimming activity and increase muscle atrophy genes, but forced swimming at low temperatures reduces these genes, suggesting exercise can prevent muscle atrophy.

This study shows that reducing CERS1 in skeletal muscle worsens age-related muscle dysfunction in mice and humans, linking it to inflammation and fibrosis.

This paper develops a self-renewing biomimetic skeletal muscle construct using induced myogenic progenitor cells that recapitulates myogenic differentiation and repair.

This study shows that DOCK3 is essential for skeletal muscle regeneration and glucose metabolism, with its loss causing metabolic dysfunction and impaired muscle repair.

The paper identifies Septin 7 as a Numb binding partner that helps maintain sarcomere structure and muscle function in aging skeletal muscle.

This study evaluates how exon skipping efficiency by antisense oligonucleotides in DMD is influenced by intron retention time and AON position within the exon.

The paper uses nanopore sequencing to analyze D4Z4 methylation gradients in FSHD, revealing length-dependent methylation patterns and CpG methylation dynamics in D4Z4 arrays.

This study shows that ultrasound-derived fascicle length measurements overestimate increases in serial sarcomere number by ~5% in rat plantar flexor muscles following chronic stretch.

The paper uses spatial transcriptomics in DMD mouse models to identify gene expression signatures linked to histopathological changes in skeletal muscle.

This study examines sexual dimorphism in skeletal muscle function and molecular composition in a mouse model of breast cancer, finding sex-specific transcriptome and contractile property differences.

This study investigates the role of sympathetic innervation in neonatal muscle growth and contractures, finding it is not required or sufficient for contracture formation but influences muscle width in a sex-specific manner.

This study examines adult stem cell fusion capacity in CP patients, finding higher fusion in Medial Gastrocnemius muscle compared to typically developing children, with reduced potency in Semitendinosus muscle.

This study identifies biphasic transcriptional changes in female skeletal muscle during cancer cachexia, distinct from males, with sex-specific gene expression patterns and implications for therapeutic targets.

This study shows that Scx-positive tendon cells are essential for proper muscle attachment and patterning in mouse embryos, revealing a novel tissue-tissue interaction in musculoskeletal development.

This study identifies Styxl2 as a regulator of de novo sarcomere assembly by promoting degradation of non-muscle myosin IIs through autophagy.

This study identifies Osr1 as essential for FAPs to support muscle regeneration by regulating communication with MuSCs and macrophages, and its loss leads to impaired regeneration and fibrosis.

This study identifies Site-1 Protease (S1P) as a negative regulator of muscle mass and mitochondrial metabolism by controlling the TGF-β target gene MSS51.

This study investigates the role of LIMCH1 alternative splicing in skeletal muscle function, showing that mLIMCH1 is essential for muscle strength and calcium handling, and that its mis-splicing is linked to myotonic dystrophy type 1.

This paper conducts a genome-wide association study to identify genetic modifiers of disease severity in dystrophinopathy patients, finding multiple candidate loci associated with age at loss of ambulation.

The paper uses single nucleus RNA-seq to identify distinct myonuclei profiles at the human myotendinous junction, revealing gene expression patterns and subclusters associated with specific proteins and fibre types.

This study shows that expressing two linker proteins in mouse models of LAMA2-related muscular dystrophy improves muscle function and prevents hindlimb paralysis.

This study identifies early molecular changes in aging mouse sciatic nerve that precede sarcopenia onset, revealing pathways linked to circadian rhythm and metabolic processes.