Regulation of Appetite and Obesity

This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.

This study identifies leptin receptor-positive neurons in the insula that regulate feeding behavior and body weight through direct interoceptive input.

This study shows that physical activity enhances gut adaptations, hormone sensitivity, and appetite regulation, aiding in body weight maintenance.

The paper investigates how glucose signaling through the vagus nerve and frontal cortex affects sucrose preference in mice, showing the role of SGLT1, dopamine receptors, and stress.

This study shows that Npas4 in POMC neurons regulates food intake during obesity by modulating inhibitory GABA-A receptor expression and neuronal activity.

This study examines how dopamine signaling in the nucleus accumbens changes during naturalistic feeding, showing transient increases during food approach that diminish with ingestion and recover between meals.

The paper maps neural activity in the mouse brainstem during food consumption, showing how different body signals are integrated across spatially clustered neurons.

This study identifies a novel target for obesity treatment by showing that inhibiting GABAergic neurons in the dorsal raphe nucleus reduces body weight in diet-induced obese mice through thermogenesis.

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

This study investigates how central leptin affects energy homeostasis and metabolism in rats exposed to olanzapine, finding that leptin's effects on food intake and fat oxidation are not blocked by olanzapine.

This study uses deep learning on structural MRI data to predict BMI more accurately than other machine learning methods in adults.

This study shows that oxytocin release during a neonatal critical period is essential for melanocortin circuit development and metabolic function.

This study shows that protein-restricted rats rapidly develop a preference for protein over carbohydrate, which is linked to increased palatability and not prior exposure.

The paper shows that serotonin and antipsychotics induce hyperphagia through distinct serotonergic receptor mechanisms, uncoupling overeating from fat storage.

This study identifies Crabp1 neurons in the arcuate hypothalamus as regulators of energy expenditure and body weight in mice through structural and functional analyses.

This study investigates the combined effects of systemic oxytocin and beta-3 receptor agonist on weight loss in diet-induced obese rats, finding additive effects on body weight and adiposity reduction.

The paper develops and characterizes Sf-1-Flp mice to study VMH-regulated physiology, showing their utility in optogenetic experiments and demonstrating the role of Adrβ2 in skeletal muscle PGC-1 response.

The paper identifies mTOR activation in POMC neurons as a key mechanism causing leptin resistance in diet-induced obese mice.

This study shows that liver-innervating vagal sensory neurons contribute to hepatic steatosis and anxiety-like behavior in mice on a high-fat diet, and their removal prevents obesity and improves metabolic outcomes.

This study identifies vagal afferents expressing the oxytocin receptor that mediate mechanosensation of the heart and gut, leading to hypometabolism and vigilance in mice.

This study shows that activating ventral pallidal GABAergic neurons increases food and sucrose consumption in male rats but not female rats.

The paper creates a cross-species atlas of the dorsal vagal complex using single-nucleus RNA sequencing and spatial profiling, revealing molecular mechanisms of cagrilintide's effects on energy balance.

This study shows overfeeding in mice does not increase energy expenditure or excretion, and weight gain is mainly countered by reduced food intake.

This study shows that obesity-associated MRAP2 variants impair multiple MC4R signaling pathways, including cAMP and IP3 signaling, and affect internalization.

This study shows that baclofen reduces body weight in mice without affecting food intake, supporting the hypothesis that GABAB receptor agonists increase metabolic rate.

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

This study shows that MCH projections to the nucleus accumbens enhance food reward value without inducing feeding or REM sleep, with sex differences observed.