Regulation of Appetite and Obesity

The paper identifies VGluT3-expressing BNST neurons that inhibit feeding via GABA transmission without affecting reward or aversion.

This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.

The paper tests if anti-obesity drugs Semaglutide and LiPR affect POMC+ neuron proportions in human and mouse hypothalamic neurons, finding no significant changes.

This study shows that a protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors in rats, with sex-dependent effects on metabolism and behavior.

The paper identifies a neural circuit involving TrhArc neurons that mediate the appetite-suppressing effects of GLP-1RAs by inhibiting AgRP neurons.

This study shows that leptin-mediated AgRP neuronal activity during postnatal life is essential for proper development of PVH oxytocin projections and autonomic regulation.

This study shows that TCMCB07, a melanocortin-4 receptor antagonist, reduces chemotherapy-induced anorexia and weight loss in rat models.

This study measures histamine dynamics during feeding in mice and finds rapid fluctuations influenced by solution type and time of day, with regional differences in recovery patterns.

The paper shows how stochastic neuropeptide signals (NPY and MSH) compete to regulate cAMP levels in neurons, influencing satiation through state-dependent integration.

The paper develops a normative framework to distinguish need and motivation in hypothalamic neurons using computational models and experimental paradigms, showing AgRP and LHLepR neurons encode need and motivation respectively.

The paper identifies BNC2 neurons in the hypothalamus that acutely suppress food intake by inhibiting AGRP neurons and are regulated by leptin, sensory cues, and nutritional status.

The paper shows early fluid homeostasis disruptions affect hypothalamic feeding circuits and alter ingestive behavior in specific contexts.

This study shows that melanin-concentrating hormone (MCH) promotes feeding via the lateral septum in both male and female mice, with context-dependent effects.

This study shows that intermittent protein restriction in male mice increases food intake and plasma ghrelin, similar to continuous protein restriction, but not in females.

This study examines sex differences in mouse hypothalamic responses to a high-fat diet, finding sex-specific effects on body weight, neuropeptide expression, and glial activation.

This study shows exenatide reduces food intake in rhesus macaques by uncoupling hedonic and anticipatory regulation from eating behavior.

This study investigates the effect of blocking glutamatergic input to the lateral habenula on palatable diet consumption in rats, finding no major acute effects but some long-term changes.

This study identifies a novel leptin-mediated pathway involving DRN-ARC neurons and serotonin to reduce food intake in rats.

This study shows that 2-monopalmitin, but not 1-monopalmitin or palmitic acid, improves hypothalamic leptin responsiveness and metabolic outcomes under overnutrition.

This study identifies a hypothalamic circuit involving ARCAgRP and MPOABRS3 neurons that modulates the prioritization of feeding and parenting behaviors during lactation.

This study shows that the chimeric peptide GEP44 reduces body weight and energy intake in diet-induced obese mice, primarily through GLP-1R signaling, with some GLP-1R-independent effects in males.

The paper measures blood ghrelin and osmolality in monkeys to assess hunger and thirst states under controlled food and water access conditions.

This study identifies agrp1 as a key regulator of breeding season-dependent feeding behavior in female medaka by linking ovarian estrogenic signals to increased food intake.

This study shows that mice lacking dopamine production in neurotensin receptor 1 neurons resist obesity on a high fat diet by not increasing daytime eating.

This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.

This study shows that mice on obesogenic diets initially attempt to maintain energy balance but eventually fail, leading to weight gain through increased meal size and frequency.

The paper identifies distinct central amygdala circuits regulating food and water uptake using intersectional genetics and in vivo calcium imaging.

This study uses fMRI to show that vicarious feeding activates motor and affective brain regions and that these responses decrease with higher BMI.

This study identifies a molecular pathway involving MC4R and Kir7.1 that mediates clozapine-induced hyperphagia and weight gain in mice.