Microtubule and mitosis dynamics

The paper identifies gene targets that modulate sensitivity to anti-microtubule drugs using CRISPR screens in human cells.

The paper quantifies phase fluctuations in axonemes after dynein motor removal, showing increased oscillation precision with motor number and distinct roles for inner and outer arm dyneins.

The paper investigates how tau-tubulin co-condensates organize microtubules through dynamic clustering and tubulin enrichment, revealing their role in network formation and adaptation.

This study identifies VezA/vezatin as a factor essential for dynactin complex assembly in Aspergillus nidulans, highlighting its role in connecting Arp1 mini-filament and pointed-end sub-complex.

This study investigates AGS3's role in spindle orientation, showing it differs from LGN due to structural differences and regulatory interactions with Insc.

The paper investigates the molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells, showing dual phosphorylation ensures robust interaction and proper mitotic progression.

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

This study investigates the kinetochore system in diplonemids, a group of protists, and suggests they may have evolved a previously unknown type of kinetochore.

This study investigates MOR1's interaction with microtubule plus ends, showing its affinity for both growing and shrinking ends and its role in polymerization and depolymerization.

The paper identifies EB-SUN, a novel microtubule end-binding protein in Drosophila, showing its role in oocyte development and functional redundancy with EB1 during embryogenesis.

This study reveals a noncanonical GTPase signaling mechanism in budding yeast where Tem1 localization, not its nucleotide state, controls MEN activation by increasing effective concentration for Cdc15 interaction.

The paper investigates how securin degradation by APC/C controls separase localization and function during meiosis I, showing its role in chromosome segregation and exocytosis.

This study shows that the CYK-4 GAP domain recruits centralspindlin to the equatorial cortex and its catalytic activity facilitates ring dissolution during cytokinesis.

Elraglusib causes cytotoxicity by directly destabilizing microtubules, leading to mitotic arrest, DNA damage, and apoptosis, independent of GSK3 inhibition.

This study shows that STIL overexpression increases centrosome numbers, leading to aneuploidy and reduced tumor formation and lifespan in mice.

The paper investigates the response to single-gene duplication in yeast, finding that translation-related genes are particularly deleterious in aneuploid cells lacking the RNA-binding protein Ssd1.

The paper investigates the distribution and interactions of gamma-tubulin complex proteins in Drosophila spermatogenesis, revealing their roles in organizing diverse MTOCs during cell organelle rearrangement.

The paper identifies the cly8 mutation as a temperature-sensitive allele of the ESP1 gene in Saccharomyces cerevisiae through whole genome sequencing and functional analysis.

This study shows that colchicine increases invasiveness in some melanoma cells by activating actomyosin, which can be counteracted by ROCK or myosin inhibitors.

The paper identifies a regulatory loop between CENP-C and Aurora B kinase mediated by the Mis12 complex, essential for correcting kinetochore-microtubule attachment errors during mitosis.

This paper uses AlphaFold to analyze the structural regulation of Polo-Like Kinase (PLK) activity, revealing domain arrangements and interactions that explain activity regulation and phosphopeptide selectivity.

This study shows that NuMA re-localization in response to mechanical stretch fine-tunes mitotic spindle orientation and dynamics.

This study identifies F-actin as part of the manchette and reveals two distinct transport mechanisms for intra-manchette transport during spermiogenesis.

The paper measures cellular forces for nuclear centration in C. elegans embryos using centrifugation and microscopy, finding forces increase linearly with distance and friction is reduced in microtubule mutants.

The paper shows that precise centriole counts are essential for B cell development but not for immune function.

This study shows PIWIL1 localizes to centrosomes during mitosis in CRC cells, affecting cell cycle progression and suggesting a role in stem cell maintenance.

The paper investigates how C. elegans meiotic chromosomes sense length to ensure proper segregation, finding that crossover sites act as diffusion boundaries for a short arm-determining factor.

The paper investigates the relationship between centrosome positioning, apical membrane formation, and polarity regulators in epithelial cells using MDCK cyst models, finding that centrosome-based polarity is not universal.

This paper elucidates how TRIM37 regulates mesoscale MTOCs through a multi-step activation mechanism involving substrate recognition, oligomerization, and dimerization.

The paper shows that kinetochores grip microtubules six-fold stronger when pulled toward plus ends, suggesting directional asymmetry in attachment strength contributes to mitotic accuracy.