Ion channel regulation and function

This study uses CRISPR to knock down Kcnq3 in NPY/AgRP neurons, reducing the M-current and increasing neuronal excitability without affecting ingestive behavior but decreasing locomotor activity.

The paper investigates the role of Kv1 potassium channels in regulating the activity of GABAergic deep cerebellar nuclear neurons using pharmacological blockers in mouse models.

The paper investigates how elevated extracellular potassium affects neuronal activity in the crab pyloric circuit, revealing transient loss followed by recovery of spiking and bursting activity.

The paper shows SCYL1 regulates Slo2 potassium channels in C. elegans and humans, with SCYL1 enhancing channel activity in human cells and reducing it in worms.

This study identifies a regulatory domain in the K2P2.1 channel that enables activation by monoterpenes, with a specific triple arginine motif essential for this effect.

The paper derives a theoretical formula linking axon initial segment geometry and sodium conductance density to somatic voltage threshold, showing how AIS position affects excitability.

The paper investigates how TNF and IL1β cytokines affect potassium channel expression in rat synovial fibroblasts, finding increased Kcnma1 and Kcnmb3 gene expression.

The paper uses a mathematical model to determine which channels control calcium spikes in sea urchin sperm, concluding that CatSper channels are responsible.

This study examines how a BK channel mutation affects synaptic plasticity and motor circuits in Drosophila larvae, finding altered neurotransmitter release and CPG dysfunction.

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

The paper identifies GstS1 as a modifier of Nav-channel mutant phenotypes in Drosophila, showing reduced GstS1 function suppresses hyperexcitability in paraShu mutants.

This study identifies Kv4.1 as a key ion channel regulating low-frequency firing in mature dentate granule cells, essential for pattern separation.

The paper investigates the role of Kvβ1 subunits in synaptic facilitation by using optical recordings in cultured hippocampal neurons, revealing their critical role in presynaptic action potential broadening.

This study shows that Slc7a5 regulates Kv1.1 channels similarly to Kv1.2, with sensitivity controlled by voltage-sensing domain exchange.

The paper investigates BK channel localization in skate electroreceptors, finding nuclear localization via an alternatively spliced NLS and showing its regulation by splicing or phosphorylation.

The paper shows that Alpha-Actinin-1 enhances CaV1.2 channel activity by localizing it to specific sites and increasing its open probability.

This paper identifies the functional requirements of the sodium leak channel complex and shows it is voltage-sensitive and modulated by extracellular calcium.

This paper uses molecular dynamics simulations to show that the S4 helix of the KvAP channel breaks into two segments under hyperpolarization and reforms under depolarization.

This study shows that calcium-induced calcium release (CICR) hyperpolarizes locus coeruleus neurons via Ca2+-activated K+ channels, suppressing their electrical activity.

The paper compares Hodgkin-Huxley and kinetic models for NaV1.5 channels, showing kinetic models better capture electrophysiological features with a rational optimization process.

The paper examines how BK channel kinetics change with age in rat hippocampal neurons, showing increased BK current contribution to action potential duration in younger neurons.

The paper shows TRAAK is localized to nodes of Ranvier and contributes to nerve conduction by modulating membrane potential and Na+ channel availability.

The paper identifies Kv2.1's role in clustering and functional coupling of L-type Ca2+ channels and RyR channels at ER-PM junctions, enabling localized Ca2+ release independent of action potentials.

The paper identifies two novel mutations in KCNJ10 and PI4KB in SeSAME syndrome patients and shows their functional impact on Kir4.1 channel activity.

This study evaluates 17 KCNB1 variants associated with DEE and NDD using high-throughput assays to identify functional defects in Kv2.1 channels.

This study compares nerve excitability in fast and slow motor axons of rats under different anaesthetics, finding significant differences in excitability indices that are affected by anaesthetic choice.

The paper experimentally validates the Hodgkin-Huxley phase diagram using dynamic clamp and Kv1.3 channels in Xenopus oocytes, revealing activity-dependent and hysteretic dynamics.

This study identifies Shox2 as a transcription factor regulating thalamocortical neuron firing properties and synaptic function through ion channel gene expression.

This study shows HCN channels modulate action potential velocity and fidelity in central axons through cAMP and neuromodulators, with implications for energy consumption and temporal delays.

This study identifies the Drosophila ERG channel (sei) as critical for neuronal homeostasis and stress resistance, with implications for human hERG mutations in seizures.