Ion channel regulation and function

The paper investigates how extracellular calcium affects neuronal excitability and finds that the Calcium-sensing receptor (CaSR) modulates voltage-gated sodium channel (VGSC) activity, influencing action potential firing rates.

The paper was withdrawn due to unreliable genetic deletion data in Kcnn3-/- mice, rendering the study's findings invalid.

This study investigates how μ opioid receptors modulate action potential kinetics and firing frequency in neocortical interneurons by targeting DTX-sensitive potassium channels.

This paper shows voltage-gated potassium channels in mixed-input ON bipolar cells adjust rod signal gain and create transient responses, enhancing dynamic range and reducing temporal redundancy.

The paper compares the cerebellar distribution of Kv1 channel subfamily members across species, finding marked differences in Kv1.4 and Kv1.6 between primates and rodents.

The paper shows that alternative splicing of sodium channels Nav1.1 and Nav1.2 has cell-type-specific effects on neuronal activity and firing properties.

This study characterizes voltage-dependent currents in cuttlefish centrifugal neurons and shows that FMRFamide reduces multiple currents, suggesting an inhibitory role in visual processing.

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

The paper measures axial current in mouse retinal ganglion cells to show how the axon initial segment supports reliable action potential backpropagation through high sodium conductance and charge preservation.

The paper investigates the role of KCNQ4-mediated M-current in regulating circadian rhythms in mesopontine cholinergic neurons and identifies its impact on neuronal synchronization and sleep-wakefulness cycles.

The paper combines experimental and computational approaches to study Nav1.7 channel behavior in human iPSC-derived sensory neurons, showing how mutations and toxins affect neuronal excitability and pain mechanisms.

The paper shows how calcineurin regulates Kcnk5b to control gene expression and allometric growth in zebrafish appendages.

The paper identifies two voltage-dependent currents that regulate the functional diversity and developmental trajectory of embryonic Renshaw cells.

The paper studies spike-frequency adaptation in a Hodgkin-Huxley-type model, showing how Na,K-ATPase and calcium-dependent potassium channels interact to shape neuronal firing patterns.

This study investigates the effects of inhibiting specific voltage-gated sodium channel isoforms on epileptiform activity in mouse cortical slices, finding that Nav1.6 inhibition is more effective than Nav1.1 inhibition.

This study uses CRISPR to knock down Kcnq3 in NPY/AgRP neurons, reducing the M-current and increasing neuronal excitability without affecting ingestive behavior but decreasing locomotor activity.

This study examines how a BK channel mutation affects synaptic plasticity and motor circuits in Drosophila larvae, finding altered neurotransmitter release and CPG dysfunction.

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

The paper investigates the role of Kvβ1 subunits in synaptic facilitation by using optical recordings in cultured hippocampal neurons, revealing their critical role in presynaptic action potential broadening.

The paper investigates BK channel localization in skate electroreceptors, finding nuclear localization via an alternatively spliced NLS and showing its regulation by splicing or phosphorylation.

This paper identifies the functional requirements of the sodium leak channel complex and shows it is voltage-sensitive and modulated by extracellular calcium.

This paper uses molecular dynamics simulations to show that the S4 helix of the KvAP channel breaks into two segments under hyperpolarization and reforms under depolarization.

The paper examines how BK channel kinetics change with age in rat hippocampal neurons, showing increased BK current contribution to action potential duration in younger neurons.

The paper experimentally validates the Hodgkin-Huxley phase diagram using dynamic clamp and Kv1.3 channels in Xenopus oocytes, revealing activity-dependent and hysteretic dynamics.

This study identifies Shox2 as a transcription factor regulating thalamocortical neuron firing properties and synaptic function through ion channel gene expression.

This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.

This study identifies lipid rafts and phospholipase D2 (PLD2) as targets of inhaled anesthetics, showing they disrupt rafts to activate TREK-1 channels and induce loss of consciousness.

The paper examines the developmental and cell-specific expression of Cacna1d splice variants, identifying patterns of exon usage in different tissues and cell types.

This study identifies four distinct domains on KCNQ3 channels where PIP2 interacts to regulate channel function, showing no coupling to voltage dependence.

This paper introduces extended electrodiffusion equations to better model NMDA receptor currents in both Ohmic and non-Ohmic conditions, showing sodium ions can block the current and revealing new insights into diffusion coefficient asymmetry.