Fungal and yeast genetics research

The paper shows that meiosis in Aspergillus fumigatus has the highest known crossover rate, producing ~29 crossovers per chromosome, and can generate azole-resistant haplotypes.

The paper compares chromatin activities in two A. fumigatus isolates, finding higher genome instability in Af293 and identifying a variant with chromosomal alterations linked to increased virulence.

The paper shows heat stress increases TPK1 mRNA levels and stabilizes it in cytoplasmic foci, impairing translation, while the CWI pathway via Wsc3 regulates this response in Saccharomyces cerevisiae.

The paper describes PomBase, a database for fission yeast, and highlights its features and contributions to the model organism database community.

The paper describes recent updates to the Saccharomyces Genome Database, including a new reference genome, allele curation system, and resources for studying human disease using yeast.

This study shows that host-produced reactive oxygen species and antimicrobial peptides induce genome instability in Candida albicans, leading to genetic changes that may enhance its adaptability.

This study combines pan-, population-, and phylo-genomic analyses of Aspergillus fumigatus to reveal population structure, lineage-specific diversity, and ecological drivers of virulence.

The paper presents a comprehensive genomic structural analysis of a pathogenic S. cerevisiae isolate using long-read sequencing, revealing extensive structural variation and its implications for genomic stability and development.

The paper identifies multiple causal DNA variants within a single gene that affect gene expression in trans in yeast, showing complexity in trans-acting variation.

The paper develops SECRiFY, a method to assess secretability of protein fragments in yeast, revealing intrinsic disorder and flexibility as key factors.

The paper shows that Saccharomycodes ludwigii undergoes meiosis without recombination, relying on frequent fertilization within tetrads instead.

The paper identifies KTD1 as a novel defense factor in Saccharomyces cerevisiae that confers resistance to the K28 killer toxin.

The paper identifies a genetic interaction between SAF1 and RLM1 in Saccharomyces cerevisiae that influences stress response, showing differential tolerance to various stressors.

This paper develops a Cre/lox-based genetic tool for markerless, repeated gene integration in Yarrowia lipolytica with high efficiency.

The paper describes engineered yeast shuttle vectors that allow efficient modification of replication loci using Cre recombinase and restriction enzymes.

The paper investigates how wtf4 meiotic drivers in S. pombe use dual transcriptional regulation and selective protein exclusion to ensure their transmission through gametes.

This study successfully humanizes the entire glycolytic pathway in yeast, revealing conserved functions and context-dependent responses.

This study identifies Mxr1p as a key regulator of ALD-A transcription and shows post-transcriptional regulation of AOX during methanol metabolism in K. phaffii.

The paper investigates stochastic switching between two heritable cell states in Candida albicans using microfluidics and fluorescent reporters, identifying two stochastic steps involving Wor1 autoregulation.

The paper identifies positively selected genes in Aspergillus fumigatus and related species, highlighting their roles in virulence, immune evasion, and adaptation.

This study shows that a single chromosome yeast strain has reduced ethanol metabolism and growth compared to wildtype.

The paper investigates how a standard knockout procedure in yeast affects the expression of neighboring genes at the translational level, revealing significant changes in protein abundance.

The paper uses RNA sequencing and DNA affinity purification sequencing to study the sulfur starvation response in Neurospora crassa, revealing CYS-3's role in regulating sulfur metabolism and related pathways.

This study restores fertility in yeast hybrids through tetraploid intermediates, enabling genetic analysis of beneficial traits and identifying QTLs for environmental tolerance.

The paper sequenced multiple Trichaptum specimens to analyze mating loci, finding long-term balancing selection maintains genetic diversity and generates many mating types.

This study investigates the roles of NoxA and Yap1 in redox homeostasis and pathogenicity of Verticillium dahliae, showing their essential functions in development, stress tolerance, and antioxidant gene regulation.

This study investigates genome plasticity in Scheffersomyces stipitis, showing that retrotransposons drive genomic diversity and rapid adaptation through chromosome rearrangements.

The paper identifies trans-regulatory mutations affecting gene expression in S. cerevisiae and shows their genomic distribution overlaps with segregating variants.

This paper identifies 532 genes involved in sexual reproduction in fission yeast using transposon-insertion sequencing, including 200 previously uncharacterized genes with vertebrate orthologs.