Cancer-related molecular mechanisms research

The paper identifies a novel lncRNA regulatory network at the BRCA1 locus that is activated during transcriptional stress induced by XPB inhibition.

The paper evaluates expression changes of PVT1, HULC, and HOTTIP in DLBCL patients before and after treatment, finding significant upregulation pre-treatment and normalization post-treatment.

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

The paper integrates DNA methylation and non-coding RNA data from breast tumor and adjacent normal tissues to identify key regulatory hubs and bottlenecks involved in transcriptional misregulation in cancer.

LCLNCRdb is a manually curated database of 1102 lung cancer-associated lncRNAs with expression, network, and survival data, providing a resource for research and data sharing.

This study identifies a novel interaction between AGO1 and NEAT1 lncRNA, showing their roles in nuclear compartmentalization and chromatin organization.

This study uses computational methods to analyze non-coding RNA regulation in human gene expression, identifying novel regulators and their targets in disease-related processes.

This study predicts and validates 320 lncRNAs in tamarind, analyzing their roles in gene regulation and biological pathways.

The paper identifies cell type-specific lncRNAs in human kidneys and finds TARID, a podocyte-specific lncRNA, is upregulated in diabetic kidney disease and critical for actin cytoskeleton reorganization.

The paper identifies a novel XACT lncRNA transcript expressed in both active and inactive X chromosomes, with roles in erythroid differentiation and AML subtypes beyond its role in XCI.

The paper creates a statistical genomics portrait of lncRNA genes for comparison with protein-coding genes to explore the non-coding genome.

The paper identifies inherited lncRNAs and circRNAs in zebrafish, finding that 20% of lncRNAs and 7% of circRNAs are inherited, with many conserved in mammals and expressed in adult tissues.

This paper identifies ADARreg, an elncRNA that modulates BCR signaling and immune evasion in lymphoma by altering RNA stability, localization, and editing, providing a potential therapeutic target.

The paper identifies a long non-coding RNA, CyKILR, with two splice variants that have opposing effects on tumor growth and cell survival in NSCLC.

This study identifies lnc-FANCI-2 as a regulator of RAS signaling in HPV16-infected cervical cancer, showing its role in lesion progression and patient survival.

The paper identifies hypoxia-responsive lncRNAs regulated by cytoplasmic mRNA capping enzyme in osteosarcoma cells under cobalt chloride-induced hypoxia.

This study investigates how NEAT1 expression changes with substrate stiffness in glioblastoma cells and shows its role in cancer progression through mechano-sensitivity.

The paper identifies a new cancer-testis long noncoding RNA, OTP-AS1, which is antisense to the OTP gene and may regulate its expression in tumors.

This study identifies HSCHARME, a lncRNA altered in cardiomyopathies, which promotes cardiomyocyte differentiation through splicing regulation.

The paper expands the lncRNA catalog using capture long-read RNA sequencing, significantly increasing the number of annotated transcripts in human and mouse genomes.

This study identifies BRE-AS1's role in modulating inflammatory activation in THP-1 cells via the miR-30b-5p/SOC3/JAK2/STAT3 pathway, showing its impact on cytokine production and signaling.

The paper identifies AD-associated lncRNAs with spatial and cell-type-specific expression patterns and shows OIP5-AS1 contributes to microglial activation in AD.

This study compares the expression of oncogenic lncRNAs NEAT1 and MALAT1 in 2D and 3D cancer cultures, showing significant differences and functional impacts in 3D tumoroids.

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.

This paper introduces CytoLNCpred, a method to predict cytoplasm-associated lncRNAs in 15 human cell lines using machine learning and DNABERT-2 embeddings, showing correlation-based models outperform LLM-based ones.

The paper identifies a polycistronic locus in Drosophila testes producing miR-317 and Peony, showing alternative polyadenylation regulates their expression and function in tumor suppression and tissue integrity.

This study investigates syntenic lncRNAs across humans and zebrafish, finding they exhibit regulatory functions through DNA elements despite limited sequence conservation.

The paper develops a workflow to detect cross-species orthology of lncRNAs across 13 vertebrate species using syntenic methods and motif analysis, revealing conserved lncRNAs and functional motifs.

This paper identifies and functionally validates the scar-6 lncRNA locus, showing it regulates prozb expression and modulates coagulation and vascular function in zebrafish through epigenetic mechanisms.

The paper identifies 2684 lncRNA genes in Anopheles gambiae using RNA-seq data and analyzes their expression and regulatory roles across different biological contexts.