Cancer-related molecular mechanisms research

This study identifies long noncoding RNAs as key regulators of pancreatic cancer identity and resistance to reprogramming.

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

This study identifies transitional lncRNAs (Tr-lncRNAs) associated with cancer progression stages and metastasis using TCGA data, revealing cancer-type specific and shared lncRNA signatures.

This study identifies LINC00673, a long noncoding RNA from a Sox9-associated super-enhancer, as critical for pancreatic regeneration and PDAC initiation by regulating cell-autonomous and non-cell-autonomous processes.

The paper identifies NeuID, a novel neuron-specific lncRNA downregulated in Alzheimer's disease, as a key regulator of neuronal identity and a therapeutic target.

This study introduces a dual CRISPRi system to target lncRNAs in melanoma cells, enabling synthetic lethal screening to identify cancer-specific lncRNA interactions for therapeutic strategies.

The paper shows that ASOs targeting CHASERR induce fusion transcripts that increase CHD2 expression, alleviating haploinsufficiency in mice.

The paper identifies lncRNAs crucial for cSCC tumor growth using CRISPRi screens and single-cell sequencing.

POCALI identifies cancer lncRNAs by integrating 44 multi-omics features, showing improved sensitivity and strong associations with cancer phenotypes.

The paper identifies how Xist Repeat A recruits SPEN via SR proteins to induce gene silencing, revealing a role for splicing factors in this process.

This study identifies PCAHIT, a lncRNA linked to poor outcomes in prostate cancer, showing it promotes aggressive phenotypes by affecting steroid biosynthesis and immune response.

This paper identifies an enhancer lncRNA that interacts with the Androgen Receptor to regulate gene expression and inhibit prostate cancer cell proliferation.

This study identifies two lncRNAs, SVALKA and SVALNA, that regulate CBF1 and CBF3 gene expression in Arabidopsis under cold stress through distinct mechanisms involving RNAPII collision and chromatin remodeling.

The paper identifies 65 novel lncRNAs differentially expressed in dengue infection and characterizes their potential regulatory roles through bioinformatics analysis.

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

The paper investigates how transcriptional stochasticity influences the regulation of Xist and Tsix at the XCI locus through different mechanisms based on nascent transcription levels.

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

eRNAkit integrates subcellular localization, RNA-RNA interaction, and expression data for eRNAs to explore their non-nuclear functions beyond traditional cis-regulatory roles.

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

The paper shows Dio3os scaffolds NuRD-HDAC1 to activate Dio3 in cis and repress thyroid-hormone-responsive osteogenic genes in trans.

The paper introduces CAR-NET, a framework for inferring non-coding RNA regulatory networks using transcriptomic data and curated databases, showing its effectiveness in simulations and case studies.

The paper reports endogenous XIST expression in male heart samples across multiple single-cell RNA sequencing studies and links it to heart disease and myocardial infarction.

The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.

The paper identifies an ultraconserved snoRNA-like element in the lncRNA CRNDE that promotes ribosome biogenesis and cell proliferation in renal cell carcinoma.

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

This paper identifies a natural antisense transcript that regulates Glut1 expression and demonstrates its therapeutic potential in Glut1 deficiency syndrome.

This study identifies XCP, a protein from the lncRNA1456, which interacts with PHF8 to regulate gene expression and cancer pathways in breast cancer.

This study identifies DANCR as a conserved lncRNA essential for zebrafish development and a human melanoma oncogene, showing its role in regulating gene expression and promoting cancer progression.

This study identifies LINC01503-MP, a mitochondrial microprotein derived from an lncRNA, which promotes cell proliferation and oxidative metabolism in colorectal cancer cells.