Bacterial biofilms and quorum sensing

This study shows that biased dispersal of a dominant bacterial species prevents competitive exclusion, enabling coexistence in multispecies biofilms.

This study identifies two quorum-sensing systems in E. faecalis that regulate purine biosynthesis, enhancing its pathogenicity in macrophages and murine infections.

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

This study shows that Pseudomonas aeruginosa uses type IV pili-mediated chemotaxis to invade and disrupt Staphylococcus aureus microcolonies, enhancing interspecies antagonism.

This study identifies a convergent evolutionary mechanism in toxin detection and resistance between Pseudomonas aeruginosa and Aspergillus fumigatus, revealing shared environmental cues and enzymatic defenses.

BBSdb is an open resource that compiles biofilm-associated proteins from multiple bacteria species and omics datasets, providing tools for prediction and exploration.

This paper introduces an in vitro model of endotracheal tube biofilms that demonstrates the effectiveness of combining matrix-degrading enzymes with antimicrobials to eradicate pathogens causing ventilator-associated pneumonia.

The paper identifies a subfamily of vanadium-dependent haloperoxidases that brominate alkyl quinolone quorum sensing signals, revealing their role in microbial chemical ecology.

This study shows that the LuxO-OpaR quorum-sensing cascade influences the lysis-lysogeny decision of phage VP882 based on host cell density and environment.

This study identifies SigF1 as a sigma factor regulating biofilm-promoting genes in Synechococcus elongatus through transcriptional and secretion pathways.

This study shows that acquiring additional quorum sensing modules reduces population size variability in Burkholderia by buffering noise in growth dynamics.

This study evaluates benzaldehyde derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa, identifying ortho-vanillin as a competitive inhibitor of RhlR.

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

This paper introduces pressorum sensing in Pseudomonas aeruginosa, showing mechanical compression triggers cAMP signaling via the Pil-Chp system, leading to increased virulence.

This study shows mucin glycoproteins enable surface dispersal of Staphylococcus aureus and S. epidermidis through mucin lubrication and quorum sensing-regulated surfactant peptides.

The paper identifies Dpr-mediated H2O2 resistance as critical for Streptococcus sanguinis survival in a polymicrobial CF airway model.

This study shows that the bacterial QS signal 2-AA modulates immune cell bioenergetics via the PGC-1α/ERRα axis, promoting immune tolerance and pathogen persistence.

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

This study investigates how flow and bacterial growth interact to control biofilm dynamics in microchannels, revealing self-sustained fluctuations due to pressure build-up and stochastic sloughing events.

The paper characterizes the functional metabolic diversity of Pseudomonas aeruginosa clinical isolates by analyzing genotype-phenotype correlations and genome-scale metabolic networks.

This study shows Pf phages and sputum polymers reduce antibiotic diffusion through electrostatic binding and liquid crystal formation in chronic Pseudomonas aeruginosa infections.

This study evaluates the effectiveness of intermittent electrochemical generation of H2O2 and HOCl against MRSA biofilms, showing that HOCl treatment duration and sequencing significantly impact biofilm reduction.

This study investigates the roughening of bacterial biofilms and finds that their surfaces remain smooth despite stochastic growth, due to a mechanism that freezes topographic fluctuations.

This study shows that lower temperatures increase RhlR activity in Pseudomonas aeruginosa through enhanced stability of the RhlR/C4-HSL/PqsE complex, affecting virulence factor expression.

This study shows that mechanical interactions and spatial constraints in confined environments limit bacterial community diversity but allow stable heterogeneous populations, even with growth advantages.

This study shows that fluid flow enhances antimicrobial delivery to overcome resistance in Pseudomonas aeruginosa by outcompeting bacterial neutralization mechanisms.

This study identifies key regulatory factors and pathways affecting swarming motility in Pseudomonas fluorescens Pf0-1, showing that Gac/Rsm pathway activation enables swarming and that Gacamide A functions as a biosurfactant.

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.