Extracellular vesicles in disease

The paper identifies a 5-gene exosomal biomarker panel with high accuracy for predicting liver metastasis in lung cancer patients.

The paper quantifies secreted and extracellular vesicle (EV) urinary proteomes in men with and without prostate cancer, showing their stability and utility in distinguishing malignant from benign lesions.

The paper assesses BEV-enrichment protocols for blood biomarkers in neurodegenerative diseases and identifies CNS-specific proteins for enrichment and biomarker use.

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.

This study shows hypoxic tumor cells release extracellular vesicles containing ALS2, which activate Rab5 in endothelial cells to promote angiogenesis via β-catenin stabilization.

This study identifies ciliary intrinsic mechanisms that regulate dynamic extracellular vesicle release from sensory neurons in C. elegans, showing that KLP-6 and TTM-5 are required for sustained release.

This study compares protein cargo differences in mesenchymal stem cell-derived extracellular vesicles isolated by three methods, finding method-specific impacts on proteome composition and biological function.

This paper shows that stress-induced Rab11a-exosomes carrying AREG promote cetuximab resistance in colorectal cancer by activating EGFR signaling in KRAS-wild type cells.

This paper introduces Membrane-Sensing Peptides (MSP) as universal affinity ligands for analyzing Extracellular Vesicles and analogues, demonstrating their ability to detect EV-associated epitopes in clinical samples without prior isolation.

The paper demonstrates that TRAIL-loaded exosomes from induced neural stem cells effectively target and kill brain cancer cells in vitro and in vivo.

EV-Checklist is a digital tool that streamlines documentation for extracellular vesicle research, improving transparency and accessibility by generating a concise PDF table for manuscripts.

The paper identifies and distinguishes extracellular vesicle and plasmodesmata proteins in Arabidopsis cell culture supernatants using proteomic and imaging analyses.

The paper uses SLAMseq to detect RNA transfer from liver to kidney in mice, finding increased transfer after liver injury.

This study investigates extracellular vesicles in urban water systems to link human activities with microbial community impacts on public health and river biodiversity.

The paper identifies that full-length tRNAs with truncated CCA tails are selectively sorted into extracellular vesicles, suggesting a new mechanism for EV cargo selection.

This study uses chiral quantum dots to investigate origin-dependent exosome uptake and cargo release mechanisms in different recipient cells.

The paper uses a single-cell transcriptomic atlas to predict cell type-specific extracellular vesicle biology, identifying gene expression patterns and networks associated with EV secretion.

The paper introduces a novel pH-based method for loading therapeutic toxins into extracellular vesicles, preserving their properties and enhancing cargo activity.

The paper identifies APE1-dependent miRNAs secreted via exosomes, showing their prognostic significance in cancer and their regulation by APE1 and hnRNPA2B1.

The paper uses cryo-TEM and a segmentation model to analyze EV architecture, finding consistent structural heterogeneity across different sources and purification methods.

The paper identifies miRNAs selectively loaded into extracellular vesicles from healthy human astrocytes and links them to neurodevelopmental disorders.

The paper identifies differentially expressed miRNAs in EVs from AA BM-MSC and links them to altered HSPC gene expression and pathways involved in cell cycle and hematopoiesis.

The paper develops a multiparametric pipeline to isolate and characterize adipose-derived extracellular vesicles from human biospecimens, identifying cell-specific biomarkers and pathways associated with obesity.

This study isolates and characterizes small extracellular vesicles directly from human brain tumor tissue, identifying novel proteins and pathways associated with these vesicles.

This paper introduces a novel large-scale EV production strategy with upstream fed-batch suspension cell culture and downstream chromatographic purification for clinical applications.

This study identifies and characterizes two types of extracellular vesicles from Cryptosporidium parvum sporozoites, revealing their unique protein compositions and potential roles in antigen presentation.

This study shows that altering the microenvironment of mesenchymal stromal cells changes exosome RNA content and improves ligament healing in rats.

The paper identifies NRXN3 as a neuron-specific marker for isolating extracellular vesicles from biofluids and develops methods to isolate these vesicles for neurological disease research.

This study isolates extracellular vesicles from human milk and neonatal digestive fluid and shows they are taken up by intestinal epithelial cells.