Pancreatic function and diabetes

The paper identifies combinatorial transcription factor expression in human islet cells and shows it correlates with functional maturity and electrophysiological activity.

This paper develops SOX9 and INS reporter cell lines to monitor and drive differentiation of human pluripotent stem cells into insulin-producing beta cells.

The paper develops a computational model of a liver-islet microphysiological system to predict glucose metabolism and translate experimental results to humans.

This study shows that mesodermal cells can differentiate into insulin-producing β-cells without endothelial specification, revealing a new pathway for β-cell regeneration in zebrafish.

This study shows that H3K4 trimethylation is necessary for the functional maturation of pancreatic islet endocrine cells by activating genes involved in glucose-stimulated insulin secretion.

This study shows that human fibroblasts can be directly reprogrammed into insulin-producing cells using a specific transcription factor cocktail.

This study maps NEUROG3 occupancy in human pancreatic endocrine progenitors, identifying 1268 target genes and linking NEUROG3 to islet cell development and type 2 diabetes risk variants.

The paper evaluates the Hnf1b-CreERT2 reporter system in adult pancreatic duct and δ cells, finding high recombination efficiency in duct cells but low in β cells and partial activation in δ cells.

The paper identifies a micropeptide encoded by a long noncoding RNA that regulates pancreatic β-cell function and insulin secretion.

This study integrates single-cell and bulk RNA sequencing data from SM/J mice to identify β-cell subpopulations and genetic networks linked to obesity and glycemic control.

This study uses multi-omics analysis of pancreatic islet donors to show heterogeneous beta cell changes associated with type 2 diabetes progression.

The paper shows that decreased KATP channel surface density in early postnatal rat beta-cells lowers the glucose threshold for insulin secretion, which normalizes by postnatal day 14.

The paper tests two models of beta cell dedifferentiation in diabetes using lineage tracing and RNA-seq in mice, showing dedifferentiation is not a reversal of development but varies by diabetes type.

This study shows that early postnatal activation of the HIF1A pathway in rats causes hyperinsulinism and reduced β-cell proliferation, potentially increasing diabetes risk.

This study identifies sexually dimorphic transcriptomes in mouse β cells and sex-dependent type 2 diabetes genes using scRNA-seq, highlighting sex differences in diabetes pathogenesis.

The paper updates a multi-level mathematical model of glucose homeostasis to better reflect organ-specific glucose uptake, dynamics, and the impact of blood flow on insulin-stimulated glucose uptake.

The paper investigates the structural effects of two rare point mutations in amylin, finding both mutations affect aggregation potential and suggest therapeutic implications for type II diabetes.

The paper presents an in silico mouse model that simulates multi-scale insulin resistance and type 2 diabetes progression across cells, organs, and the whole body.

This study identifies glucocorticoid-responsive gene regulatory programs in pancreatic islets and links them to type 2 diabetes risk through chromatin and gene expression analysis.

This study investigates the effects of TCF19 overexpression in pancreatic beta-cells, revealing increased DNA damage response and inflammatory gene expression.

The paper uses single-cell chromatin accessibility to identify cell type- and state-specific regulatory programs associated with type 2 diabetes risk.

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.

The paper compares 10 machine learning workflows to identify genes associated with insulin transcript presence in human pancreatic single-cell transcriptomes, finding Random Forest to be highly predictive.

This paper generates a Nkx6-1 Venus fusion reporter mouse line to track and isolate Nkx6-1-expressing cells, including pancreatic β-cells, during development and in adult tissues.

The paper shows REST inhibits pancreatic endocrine differentiation in mice, zebrafish, and human organoids, identifying it as a key negative regulator.

The paper shows human gallbladder epithelial cells retain a pro-endocrine pancreatic transcriptional program, enabling insulin production and immune protection in type 1 diabetes.

The paper identifies a core set of developmentally and evolutionarily conserved PDX1-bound genes in mouse and human pancreas development, showing stable PDX1 binding across ages with context-dependent regulatory roles.

The paper identifies T2D risk variants in pancreatic progenitor-specific enhancers and shows their role in regulating developmental genes involved in pancreas morphogenesis.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

This study uses single-cell RNA-seq and mitochondrial variants to trace lineage differences between alpha and beta cells in human pancreatic development, revealing distinct developmental trajectories not seen in mice.