Bacteriophages and microbial interactions

The paper reports the complete genome sequence of CpV-BQ1, a phycodnavirus infecting Chrysochromulina parva, and shows its phylogenetic relationship to other viruses in the Megaviricetes phylum.

This study shows that bacteriophage exposure induces DNA inversions in Bacteroides fragilis, enhancing genomic and phenotypic plasticity to adapt to phage predation and gut colonization.

The paper demonstrates a synergistic bactericidal effect of low-dose pulsed blue light and phage therapy on Pseudomonas aeruginosa planktonic cultures and biofilms.

The paper identifies novel phage resistance systems encoded in mobile integrons and shows they can be combined for multi-phage and antibiotic resistance with variable fitness costs.

The paper identifies multiple Nucleocytoviricota virus infections in the brown algae Undaria pinnatifida through genome analysis.

The paper aggregates nine existing human gut viral catalogues and expands them with new data to create AVrC, a unified resource containing over a million viral sequences.

This study identifies a reversible genetic mechanism in Salmonella Typhimurium that confers phage resistance by deleting the wzy locus, enabling recovery after phage predation.

This paper isolates and characterizes a new Escherichia phage, AUBRB02, from sewage in Beirut, Lebanon, highlighting its potential for phage therapy due to its lytic activity and stability.

This study identifies viruses from hydrothermal vents and shows that while many are endemic, some share proteins related to core functions, suggesting geology influences viral ecology and host coevolution.

This study isolates and characterizes virulent bacteriophages targeting Enterobacteriaceae from preterm piglets with NEC-like inflammation, showing their potential for phage therapy.

This study develops and tests phage therapy medical products (PTMPs) against carbapenem-resistant Klebsiella pneumoniae ST512 strains, showing partial efficacy and the need for antibiotic combination.

This study compares plasmid and phage populations in gut microbiota of Parkinson's disease patients and healthy controls, finding significant differences in diversity and using machine learning to classify subjects with high accuracy.

The paper presents 230 new GV genomes and 398 partial genomes from nine ocean datasets, revealing new functions and a functional divide between GV orders.

This study isolates and characterizes two phages effective against ESBL-producing E. coli and CREC, showing enhanced lysis and survival rates when combined with antibiotics.

This paper introduces Meta-SIFT, a method to discover functional sequence motifs in metagenomes to engineer bacteriophage activity, demonstrating its utility in creating variants with novel host specificity.

Phollow tracks phage replication and spread in zebrafish guts with single-virion resolution, revealing rapid uptake by intestinal cells and antibiotic-induced shifts in microbial communities.

The paper identifies and characterizes seven new lytic phages infecting Klebsiella, confirms their classification as Webervirus, and identifies a new genus, while highlighting their potential as therapeutic agents against multidrug-resistant strains.

This study analyzes the structure-function relationships and evolutionary origins of cell wall-binding domains in staphylococcal phage endolysins, finding that CBD specificity is not strongly correlated with phylogeny or host specificity.

This paper discovers a novel lytic phage, Mystique, that infects a broad range of Acinetobacter baumannii strains and shows that environmental conditions significantly affect phage infectivity and isolation outcomes.

The study examines the virome of fresh vegetables and its transmission to the human gut, finding that vegetable viruses contribute to gut virome diversity.

The paper identifies an active giant endogenous virus in Chlamydomonas reinhardtii, showing viral production and latent infection dynamics in natural isolates.

This study shows that filamentous bacteriophages like M13 induce proinflammatory responses and inhibit bacterial internalization in intestinal epithelial cells.

The paper tests lysogeny in Microcystis blooms using mitomycin C and finds it ineffective for inducing prophage, suggesting standard protocols are unsuitable for freshwater cyanobacterial studies.

This paper introduces PHORCE, a method to quantify phage amplification rates and reveals wide variation in phage-antibiotic interactions across Escherichia coli phages.

This paper introduces predicted phage host families to improve cross-study comparisons of gut viromes by reducing ecological distances and detecting disease-specific signatures.

The paper completes the BASEL phage collection by overcoming host limitations to isolate new phages, revealing insights into viral host recognition and bacterial immunity.

The paper identifies a phage-encoded counter-defense gene that inhibits a bacterial NAD-degrading anti-phage defense system, enabling phage survival.

The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.

This study investigates the incomplete lytic cycle of hankyphage, a Bacteroides bacteriophage, revealing defective virion formation and incomplete DNA packaging.

This study investigates phage-bacteria interactions in PHA-MMCs using meta-omics, revealing phage influence on community structure and PHA synthesis pathways.