Photoreceptor and optogenetics research

This study introduces a method to control medaka behavior using optogenetics with channelrhodopsin, showing light-induced movements in embryos, larvae, and adults.

The paper demonstrates that optogenetic actuators in starburst amacrine cells enhance visual restoration in murine retinas through gap junctions.

This paper introduces an optogenetic voltage-clamp technique for precise control of cellular voltage in live animals, demonstrating its application in C. elegans and rat neurons.

This paper introduces FLiT, a method for ultra-fast sequential light targeting to enable precise and scalable control of neuronal networks.

The paper identifies a mutation that enhances the sensitivity of a fluorescent voltage indicator, improving its ability to detect both spiking and subthreshold voltage signals in multiple organisms.

This paper describes a surgical method for implanting an Opto-Array in nonhuman primates to enable high-throughput optogenetic stimulation and behavioral testing.

The paper introduces a bicistronic AAV vector that co-expresses GCaMP8s and stChrimsonR in mice, enabling stable and robust two-photon holographic stimulation and imaging of cortical neurons.

The paper develops optogenetic tools that control protein-protein interactions using light in multiple colors by engineering binders for different states of cyanobacteriochromes.

This paper develops a framework for optogenetic control of the auditory pathway by optimizing light pulse parameters to enhance spike probability and information encoding in spiral ganglion neurons.

This paper introduces optoSynC, an optogenetic tool that rapidly and reversibly silences synaptic transmission by clustering synaptic vesicles in C. elegans.

This paper demonstrates the use of PhoCl, a photocleavable fluorescent protein, to achieve optical control over protein cleavage in zebrafish embryos, enabling light-triggered protein translocation and apoptosis.

The paper presents cryo-EM structures of ChRmine, a microbial channelrhodopsin, in lipid nanodiscs, revealing its trimeric architecture and structural basis for its unique optogenetic properties.

This paper develops an optogenetic method to control arteriole diameter in 3D with high spatiotemporal resolution, enabling study of vascular dynamics and blood flow regulation.

The paper implements and optimizes a novel optogenetic tool in mammalian cells using a split T7 RNA polymerase system for light-inducible gene expression control.

This paper introduces a neuropsin-based optogenetic tool, cOpn5, that enables precise control of Gq signaling with high temporal and spatial resolution.

This study shows that mutations in retinochrome opsin's binding pocket cause spectral tuning through epistatic interactions rather than additive effects.

The paper compares the behavioral effects of two optogenetic channelrhodopsin variants, finding that ChETA suppresses aggression while ChR2 increases it in mice.

The paper reevaluates the efficacy of nonhuman primate optogenetics for psychiatry, finding lower success rates when applying more relevant criteria to human neuropsychiatric disease.

The paper engineers an improved fluorescent chloride sensor using directed evolution and coevolutionary analysis in E. coli.

This paper engineers high-performance microbial opsins for precise spatial and temporal control of neuronal networks, enabling large-scale activation of defined neurons in vivo and in vitro.

The paper develops and tests a novel optogenetic silencer, PACK, in healthy and epileptic mice, finding it effectively inhibits neuronal activity but causes side effects.

This paper introduces a method to enhance two-photon optogenetic stimulation in live mouse brains by using fluorescent molecules to improve opsin activation efficiency.

The paper investigates the relationship between pulse duration and optical power in optogenetic stimulation of dopamine neurons, finding a constant product of power and duration for reward seeking.

This study shows that optogenetic stimulation of the primate retina can activate the visual cortex for over 20 months, demonstrating long-term functionality and signal transmission.

The paper develops a chronically implantable LED array for optogenetic perturbation in non-human primates and demonstrates its effectiveness in inducing visual deficits.

This study uses genetic code expansion and optical targeting in C. elegans to selectively activate gene expression in specific neurons and analyze their role in behavior.

BiPOLES is an optogenetic tool that allows bidirectional control of neuronal activity using two different light colors, enabling both excitation and inhibition of the same neurons in a single experiment.

This paper demonstrates the use of X-ray-induced scintillation to remotely control neural function in mice, achieving bidirectional modulation of behavior through optogenetic activation and inhibition.

This paper introduces parapinopsin (PPO), a photoswitchable GPCR-based opsin that enables rapid and reversible presynaptic inhibition, and demonstrates its utility in vivo.

The paper develops a novel genetically encoded voltage indicator, NovArch, enabling high-resolution voltage imaging in brain tissue with improved sensitivity, background rejection, and time resolution.