Cancer, Lipids, and Metabolism

This paper shows that inhibiting SCD1 with MF-438 enhances TMZ effectiveness in IDH1-mutant glioma mouse models by inducing lipotoxic stress and ferroptosis.

This study identifies lysosomal lipid metabolism as a driver of pancreatic cancer cell invasion through local energy production and membrane remodeling.

The paper identifies malonate as an endogenous intermediate supporting mitochondrial fatty acid synthesis and oxidative phosphorylation, showing ACC1-dependent synthesis from glucose.

This study examines how high-fat and high-iron diets affect liver tumorigenesis and transcriptomic changes in mice, finding shared and distinct molecular effects.

This study identifies PI(4,5)P2's role in lysosome positioning through cholesterol trafficking in p53-deficient cancers.

This study identifies a 10-gene mitochondrial fatty acid oxidation suppression signature common across breast cancer subtypes, validated in multiple cohorts and associated with survival.

This study shows that LEO1 loss in colorectal cancer promotes ER stress-adapted migration and cholesterol dependency, suggesting therapeutic targets for metastatic LEO1-low CRC.

This study shows that avasimibe restores sorafenib's anticancer effect in hypercholesterolemia-induced hepatocellular carcinoma by enhancing cytotoxicity and reducing ERK signaling.

This study shows that FASN inhibition restores radiosensitivity in chordoma by targeting adaptive fatty acid metabolism that protects against radiotherapy-induced damage.

This study identifies that 3q-gain aneuploidy in squamous cell carcinomas creates a vulnerability to SREBP-pathway inhibition, offering a target for lipid-targeted therapies.

The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.

The paper identifies CPT1A loss as a driver of lung metastasis in immune-competent mice through mtDNA release and STING pathway activation, with clinical relevance in breast cancer.

This paper identifies a bidirectional interaction between the SREBP pathway and nesprin-4 that regulates lipid metabolism and proposes it as a therapeutic target for metabolic disease.

This study shows that renal CoA production from VB5 supports gut stem cell proliferation and tumor growth in Drosophila, with implications for human cancer.

This paper develops CIRCMIP to profile intratumoral microbiota, identifies Staphylococcus lugdunensis as a bladder cancer biomarker, and reveals its metabolic role via LPC14:0-PPARδ signaling.

This study identifies METTL7B as a regulator of lipid metabolism and tumor progression in pancreatic cancer, showing its role in promoting cell proliferation, migration, and metastasis.

The paper shows that fatty acid synthesis supports tumor progression by maintaining TORC1 sensitivity to Insulin/PI3K signaling through ACC-dependent mechanisms.

This study identifies how adipocyte secretome induces metabolic and epigenetic changes in TNBC cells, promoting stress-adaptive states through chromatin remodeling and metabolic reprogramming.

This paper identifies ACSS1 as a metabolic driver in lymphomas, showing its role in acetate-to-acetyl-CoA conversion and pyrimidine biosynthesis, and demonstrates that targeting ACSS1 suppresses tumor growth.

The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.

This study shows SCD1 and SCD5 modulate DNA repair in glioblastoma via fatty acid desaturation, with SCD5 specifically affecting sphingolipids and PARP1 activity.

This study identifies a unique metabolic plasticity mechanism in AML cells through protein S-acylation, which is inhibited by TOFA and a glutaminase inhibitor combination.

This study shows that inhibiting FASN leads to lysosome-dependent cell death via GRN expression, suppressing leukemogenesis in myeloid leukemia.

This study identifies FASN inhibition as a therapeutic strategy for NF2/CDKN2A-deficient MPM, showing reduced tumor growth in xenograft models.

This study shows Rab5's GTPase cycle regulates lipid droplet dynamics in HCC cells, promoting β-oxidation and proliferation by sustaining mitochondrial energy production.

The paper integrates transcriptomic and lipidomic data to identify gene regulatory networks involved in colonocyte differentiation and their disruption in colon cancer.

This study introduces CL-MFA to quantify lipid metabolic fluxes in NSCLC models, revealing LKB1 regulation of sphingolipid recycling and fatty acid synthase upregulation under standard culture conditions.

This study shows that cholesterol biosynthesis is critical for myofibroblastic CAFs to remodel the extracellular matrix and promote tumor metastasis.

This study shows that modulating cholesterol metabolism in ovarian cancer cells enhances CAR-T cell cytotoxicity by disrupting lipid storage mechanisms.

This study identifies a metabolic vulnerability in colorectal cancer where combining HIF-2 inhibition with cholesterol biosynthesis inhibition using statins enhances ferroptosis, offering a new therapeutic strategy.