Cancer, Lipids, and Metabolism

Fatty acid synthase coordinates mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy

This study identifies FASN as a regulator of mTOR signaling and histone crotonylation during cardiomyocyte hypertrophy, linking lipid metabolism to epigenetic changes and cardiac disease.

De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.

FASN-driven lipogenesis sustains EGFR palmitoylation and PI3K-AKT-mTOR signaling, suppressing tumor MHC-I antigen presentation; blocking it curbs TNBC metastasis in mice via CD8 T cell recognition.

ANO6 Scaffolds ER Mitochondria Contacts to Govern Spatial Lipid Compartmentalization and Ferroptosis Evasion in Chemoresistant Breast Cancer

This study identifies ANO6 as a scaffold at ER-mitochondria contacts that facilitates lipid sequestration and ferroptosis evasion in chemoresistant breast cancer.

Reversible, Orally Bioavailable Small-Molecule Inhibitors Occupy the Substrate Tunnel of the Thioesterase Domain of Fatty Acid Synthase

This paper reports the discovery of SBP-5917, a reversible FASN-TE inhibitor with submicromolar potency and cellular target engagement.

KRAS-driven metabolic reprogramming of enhanced MFSD2A-mediated lysophosphatidylcholine scavenging promotes survival and progression of pancreatic ductal adenocarcinoma

This study identifies KRAS-driven metabolic reprogramming through MFSD2A-mediated lysophosphatidylcholine scavenging as a driver of PDAC progression and shows that targeting this pathway with edelfosine has anti-cancer effects.

A Novel ACLY Inhibitor Induces Transcriptional and Metabolic Reprogramming to Overcome Tyrosine kinase inhibitor Resistance in Lymphoma

This paper identifies VCB1, a novel ACLY inhibitor, which overcomes TKI resistance in lymphoma by disrupting lipid and nucleotide metabolism, ISR, and redox homeostasis.

Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma

This paper identifies treatment-resilient lipid remodeling in TMZ-resistant glioblastoma cells, showing that resistance is linked to coordinated changes in multiple lipid families rather than single species.

ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesisand fatty acid oxidation in colorectal cancer

This study identifies ALDH1B1's role in mitochondrial GBB and GABA biosynthesis, enhancing fatty acid oxidation in CRC and linking it to tumor progression.

Saturated fatty acid chain length shapes B cell lymphoma metabolism and progression

This study shows that dietary saturated fatty acid chain length affects B-cell lymphoma metabolism and progression, with medium-chain fatty acids promoting tumor growth and long-chain fatty acids restricting it.

Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression

This study shows that inhibiting de novo lipogenesis and supplementing with PUFAs suppresses prostate cancer progression by inducing oxidative stress and cell death.

Metabolic Targeting of SREBP1 Reprograms the Obesity-Driven Ascites Immune Microenvironment and Enhances Chemotherapy Response in Obesity-Associated Ovarian Cancer

This study shows that inhibiting SREBP1 with Nelfinavir improves chemotherapy response in obesity-associated ovarian cancer by reprogramming the immune microenvironment.

Targeting Tumor Immunity: Statins as a Repurposed Strategy for Preventing Ovarian Cancer Advancement

This study investigates the effect of statins on ovarian cancer survival, finding that atorvastatin improves survival and enhances immune activation in preclinical models.

Targeting Cholesterol-Dependent Piezo1 Activation Impairs Amoeboid Migration in Melanoma Cells

This paper identifies statins as inhibitors of bleb-based migration in melanoma cells by reducing cholesterol, which disrupts Piezo1 function and impairs migration in confined environments.

Simultaneous Inhibition of ACLY and OGDH Has a Synergistic Effect on Hepatocellular Carcinoma Cell Lines

This study shows that combining ACLY and OGDH inhibitors VPA and BA synergistically inhibits HCC cell lines with minimal toxicity to normal liver cells.

Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor

This paper identifies TMEM132A as a pan-cancer target that stabilizes EGFR and drives lipid synthesis, and develops a nanobody to inhibit this interaction, showing antitumor activity in resistant models.

Phosphoglycerate mutase 5 regulates lipid metabolism and mitochondrial homeostasis in hepatocellular cancer cells

This study shows that PGAM5 loss in hepatocellular cancer cells disrupts lipid metabolism and mitochondrial homeostasis by altering bioenergetics and phospholipid pathways.

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

This study identifies cholesterol dependency as a therapeutic target in glioblastoma, showing that combined treatment with clemastine and bexarotene induces metabolic collapse and enhances antitumor immunity.

Site-specific cholesterol depletion therapy for gastric cancer

This study identifies site-specific cholesterol elevation in gastric cancer cells and shows that inhibiting NPC1L1 with ezetimibe reduces cholesterol levels and suppresses cancer growth.

Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation

This study identifies glutamine as a carbon source for lipogenesis during HCMV infection through reductive carboxylation, contributing to lipidome remodeling.

Medulloblastoma Forms Symbiotic Metabolic Partnerships with Macrophages to Establish Leptomeningeal Metastases

This study identifies metabolic partnerships between medulloblastoma and macrophages that drive leptomeningeal metastases and suggests targeting the CXCL12-SCARB1-cholesterol axis as a therapeutic strategy.

A Stress-Adaptive Lipid Kinase Axis Defines Metabolic Vulnerabilities in Neuroendocrine Prostate Cancer

This study identifies a stress-lipid kinase axis in NEPC driven by PIKfyve, revealing a synthetic vulnerability between PIKfyve and FASN that can be exploited for therapeutic targeting.

Human bone marrow adipocytes drive prostate cancer bone metastasis progression via lipid-mediated induction of Angiopoietin-like 4

This study identifies BMAds as drivers of prostate cancer bone metastasis through lipid-mediated induction of ANGPTL4, showing its clinical relevance as a therapeutic target.

PCIF1 loss licenses antitumour immunity via cholesterol biosynthesis

This study shows that PCIF1 loss enhances cholesterol biosynthesis, promoting antitumour immunity by increasing CD8+ T cell infiltration and improving response to immune checkpoint blockade.

Mechanism of fatty acid uptake and inhibition in human FATP2

This paper presents cryo-EM structures of human FATP2, revealing its fatty acid uptake mechanism and drug inhibition strategies.

Acidosis-triggered fatty acid overload induces endothelial cell dysfunction.

This study shows acidosis enhances fatty acid uptake in endothelial cells, leading to lipid droplet formation, ER stress, and reduced nitric oxide, contributing to endothelial dysfunction.

Toward pharmacologic therapy for glioblastoma: Characterization of the very long-chain acyl-CoA synthetase 3 (ACSVL3) inhibitor Grassofermata

This study identifies CB5 (grassofermata) as a potential inhibitor of ACSVL3, showing reduced glioma cell growth and malignancy in vitro and in vivo.

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

ACSS2-Mediated Metabolic-Epigenetic Crosstalk Drives Fulvestrant Resistance and Represents a Novel Therapeutic Target

This study identifies ACSS2-mediated metabolic-epigenetic crosstalk as a driver of Fulvestrant resistance in ER+ breast cancer and presents ACSI as a potential therapeutic target.

Comparative profiling of carnitine palmitoyltransferase 1 isoforms reveals vincamine as a selective carnitine palmitoyltransferase 1b inhibitor

This study identifies vincamine as a selective CPT1b inhibitor using a high-throughput assay, expanding the known isoform profile of chlorpromazine and demonstrating the feasibility of selective CPT1 isoform modulation.

TAp63-regulated oncogenic long non-coding RNA-8 ( TROLL-8 ) regulates human breast cancer progression through CPT1A-mediated fatty acid oxidation

This study identifies TROLL-8 as a regulator of fatty acid oxidation in breast cancer, showing its role in promoting tumorigenesis through CPT1A interaction.