Cancer, Lipids, and Metabolism

This study shows that IR-B deficiency in prostate cancer accelerates tumor progression through PI3K/AKT signaling and fatty acid dysregulation, with omega-3 fatty acids having opposing effects.

This study shows that autophagy and cholesterol metabolism are remodeled in glioma progression and TMZ resistance, with impaired autophagy linked to reduced cholesterol synthesis and altered lipid profiles.

The paper identifies genetic suppressors of FASN dysfunction in C. elegans by using temperature-sensitive mutants and CRISPR/Cas9 to rescue embryonic lethality.

The paper identifies that Snail-induced chemoresistance in cancer cells is linked to an imbalance in lipid metabolism, specifically through the repression of sphingomyelin biosynthesis and upregulation of ABCA1.

The paper demonstrates that statin-dye conjugates are selectively taken up by KRAS mutant cancer cells through enhanced macropinocytosis, enabling targeted killing of these cells without affecting KRAS wild-type cells.

This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.

This study shows that adaptation to cystine limitation stress in PDAC promotes tumor growth via lipid metabolism reprogramming, and lomitapide can inhibit this process and enhance chemotherapy.

The paper links lower plasma plasmalogen levels to increased risk of lymph node positive breast cancer in humans and mice, showing dietary PUFA depletion promotes cancer survival in lymph nodes.

This study shows licochalcone A suppresses breast cancer growth by targeting SREBP1-dependent lipogenesis and inflammation.

This study shows that inhibiting cholesterol biosynthesis in rhabdomyosarcoma cells induces ER stress, apoptosis, and cell cycle arrest, suggesting a new therapeutic strategy for this aggressive cancer.

This study identifies SOAT1 as a target for improving immunotherapy and reducing liver cancer relapse by blocking cholesterol esterification.

This study shows that propionate metabolism dysregulation, through MMA accumulation and EMT activation, promotes drug-tolerant persister cell survival in NSCLC.

This study shows that medium-chain fatty acid exposure in non-transformed mammary glands induces aging-like changes linked to breast cancer risk.

This study identifies mevalonate biosynthesis as a therapeutic target and biomarker for gemcitabine-resistant pancreatic cancer.

This study shows that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell metabolism and function in response to nutrient abundance, affecting tissue homeostasis and regeneration.

This study identifies glycolysis-stratified coordination between fatty acid and glutamine metabolism in PDAC, revealing context-dependent metabolic dependencies and potential therapeutic targets.

This study identifies a non-canonical metabolic pathway in cancer cells that uses β-hydroxybutyrate for fatty acid synthesis, supporting tumor growth under lipid-limited conditions.

This study identifies PI5P4K as a regulator of iron homeostasis in pancreatic cancer cells, showing its role in metabolic fitness and tumor growth.

This study shows that hyperlipidemia, not obesity alone, drives breast cancer growth in mice, suggesting lipid-lowering therapies could reduce cancer risk in obese individuals.

This study investigates the role of long chain acyl-CoA synthetases in MASH-HCC and ferroptosis, identifying ACSL4 as a key player in lipid metabolism and immune microenvironment.

The paper shows that gap junctions between breast cancer cells and adipocytes transfer cAMP, activating lipolysis in the tumor microenvironment to support tumor growth.

This study shows the mevalonate pathway supports amino acid synthesis by promoting mitochondrial NAD regeneration through ubiquinone-dependent electron transport, and statin inhibition disrupts this process.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

The paper shows that palmitoylation of NADK by ZDHHC5 enhances NADP+ synthesis and promotes tumorigenesis in pancreatic cancer.

This paper identifies potential inhibitors of ACSVL3, an enzyme overexpressed in glioblastoma, using in vitro assays and a high-throughput screening approach.

This study shows SCD inhibition in prostate cancer reduces tumor growth in bone by affecting cellular stress, mTOR, and DNA damage pathways.

This study identifies fatty acid desaturases SCD1 and FADS2 as critical for EBV-induced B cell proliferation and reveals their role in promoting metabolic pathways that support lymphoma growth.

This study uses chemical probes to assess HMGCS1 inhibition, showing similar proteome effects to HMGCR inhibition and demonstrating efficacy in statin-resistant models.