Cancer, Stress, Anesthesia, and Immune Response

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

This study shows that nociceptor neurons promote immunosuppression in tumors by increasing MDSC infiltration and CD8+ T cell exhaustion through IL-6 and sEVs.

This study establishes a DRG-nerve explant model for perineural invasion (PNI) and identifies molecular and cellular features of PNI in cancer cells.

This paper shows that melanoma progression in zebrafish is linked to nerve growth and catecholamine signaling, suggesting new therapeutic targets.

This study examines how cancer surgery affects T and B cell responses to a model antigen, showing reduced cytokine-producing CD8+ T cells and antibody-secreting B cells post-surgery.

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

This study identifies neuronal substance-P as a driver of breast cancer growth and metastasis through an extracellular RNA/TLR7 signaling axis, with therapeutic targeting showing efficacy in mouse models.

This study shows pancreatic Schwann cells reprogram during cancer development, promoting sympathetic nerve sprouting and a protective antitumor response.

This study develops methods to label and subtype sensory neurons interacting with breast cancer cells using retrograde tracers and mouse models.