Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxiv
Climatic drivers of Verticillium dahliae occurrence in Mediterranean olive-growing areas of southern Spain
J. M. Requena-Mullor, J. M. Garcia-Garrido, P. A. Garcia, E. Rodriguez
This study identifies climatic drivers of Verticillium dahliae occurrence in olive groves in southern Spain, finding that isothermality and seasonal precipitation distribution are key factors.
DOI 10.1371/journal.pone.0232648 - PathologybioRxiv
iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile
C. C. Duwaerts, C. L. Her, N. J. Phillips…·J. J. Maher
The paper generates iPSC-derived hepatocytes from NAFLD patients to identify disease-specific gene expression profiles without metabolic challenge.
- PathologybioRxivPreprint
Cadherin-6 mediates thrombosis in vivo
E. G. Bouck, M. de la Fuente, E. R. Zunica…·M. T. Nieman
This study investigates cadherin-6's role in thrombosis using murine models, finding that blocking or deleting cadherin-6 delays occlusion, while human platelets express it but murine do not.
DOI 10.1101/2020.04.20.051045 - PathologyPLOS Neglected Tropical DiseasesPeer-reviewed
Does skin surface temperature variation account for Buruli ulcer lesion distribution?
N. K. Sexton-Oates, A. Stewardson, A. Yerramilli, P. Johnson
This study investigates whether skin surface temperature variation explains Buruli ulcer lesion distribution, finding a weak inverse correlation between cooler skin temperatures and higher lesion incidence.
- PathologybioRxiv
Targeted sequencing of FH-deficient uterine leiomyomas reveals biallelic inactivating somatic fumarase variants and allows characterization of missense variants
B. Popp, R. Erber, C. Kraus…·A. Agaimy
The paper identifies biallelic somatic fumarase variants in FH-deficient uterine leiomyomas and estimates germline FH variant carrier frequency.
DOI 10.1038/s41379-020-0596-y - PathologybioRxiv
Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice
H. Sawada, M. K. Franklin, J. J. Moorleghen…·A. Daugherty
This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.
- PathologybioRxivPreprint
Significant expression of FURIN and ACE2 on oral epithelial cells may facilitate the efficiency of SARS-CoV-2 entry
Z. Mei, L. Bingpeng, G. Hongbin…·W. Lijing
The paper investigates the expression of FURIN and ACE2 in oral epithelial cells and finds they may facilitate SARS-CoV-2 entry through two potential routes.
DOI 10.1101/2020.04.18.047951 - PathologybioRxiv
Towards resilient beef cattle production systems: Impact of truck contamination and information sharing on foot-and-mouth disease spreading
Q. Yang, D. M. Gruenbacher, J. L. Heier Stamm…·C. M. Scoglio
This study uses an agent-based model to analyze how truck contamination and information sharing affect foot-and-mouth disease spread in U.S. cattle production systems, showing increased disease spread with indirect contact and improved resilience with information sharing.
DOI 10.1371/journal.pone.0240819 - PathologybioRxiv
Informing epidemic (research) responses in a timely fashion by knowledge management - a Zika virus use case
A. Bauch, J. Pellet, T. Schleicher…·M. D. de Jong
This paper develops a knowledge repository for Zika virus research to rapidly integrate pathophysiological knowledge during outbreaks, enabling faster response and hypothesis generation.
DOI 10.1242/bio.053934 - PathologybioRxiv
Development and validation of a real-time RT-PCR test for screening pepper and tomato seed lots for the presence of pospiviroids
M. Botermans, J. W. Roenhorst, M. Westenberg…·D. C. M. Beugelsdijk
The paper develops and validates a real-time RT-PCR test called PospiSense for detecting seven pospiviroids in pepper and tomato seeds.
DOI 10.1371/journal.pone.0232502 - PathologybioRxivPreprint
Review of histopathologic findings of endometrial biopsy done at a tertiary referral hospital in urban Ethiopia.
L. Belay Tolu, S. Kebtamu, M. Abedella…·E. Senbeto
The paper reviews histopathologic findings of endometrial biopsies in urban Ethiopia, finding endometrial polyps as the most common result and highlighting issues with sample adequacy.
DOI 10.1101/2020.04.16.044610 - PathologybioRxiv
Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice
L. Muniappan, M. Okuyama, A. Javidan…·V. Subramanian
This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.
DOI 10.1161/atvbaha.120.315546 - PathologybioRxiv
Severe asthma is associated with a remodeling of the pulmonary arteries in horses.
S. Ceriotti, M. Bullone, M. Leclere…·J.-P. Lavoie
This study shows that severe equine asthma causes pulmonary artery remodeling with increased smooth muscle mass, which is partially reversible by antigen avoidance but not corticosteroids.
- PathologyScience Translational MedicinePeer-reviewed
Nimodipine prevents the development of spasticity after spinal cord injury
M. Marcantoni, A. Fuchs, P. Low…·C. Bellardita
This study shows that nimodipine prevents spasticity after spinal cord injury in mice by targeting neuronal CaV 1.3 channels.
DOI 10.1126/scitranslmed.aay0167 - PathologybioRxiv
A new automated chilled adult release system for the aerial distribution of sterile male tsetse flies
C. Mirieri, G. N. Mutika, J. Bruno…·A. M. M. Abd-Alla
This paper tests a new automated chilled release system for sterile male tsetse flies, finding it maintains flight and mating competitiveness but reduces survival.
DOI 10.1371/journal.pone.0232306 - PathologybioRxiv
Does the Antisecretory Peptide AF-16 modulate fluid balance and inflammation in experimental peritonitis induced sepsis?
A. Barrueta Tenhunen, J. Tenhunen, J. van der Heijden…·R. Feinstein
This study tests whether AF-16 modulates sepsis symptoms in fecal peritonitis but finds no significant differences between AF-16 and saline groups.
DOI 10.1371/journal.pone.0232302 - PathologybioRxivPreprint
Presence of polyadenylated 3' tail in RNA of Pepper mild mottle virus allows the Oligo(dT)18 in Priming cDNA Synthesis of its genomic RNA template
N. Kumari, V. Sharma, S. Choudhary, P. N. Sharma
This study shows that Pepper mild mottle virus (PMMoV) genomic RNA has polyadenylated 3' tails, allowing oligo(dT)18 priming despite lacking poly(A) tails in its 3' UTR.
DOI 10.1101/2020.04.13.039180 - PathologybioRxivPreprint
Multiscale three-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
G. Li, S. E. Fox, B. Summa…·J. Q. Brown
This study presents the first 3D images of COVID-19 lung autopsy tissues using high-resolution cleared tissue microscopy, offering new insights into disease processes contributing to mortality.
- PathologybioRxivPreprint
Python nidoviruses, more than respiratory pathogens
E. Dervas, J. Hepojoki, T. Smura…·A. Kipar
This study investigates python nidoviruses, finding they infect multiple tissues beyond the respiratory tract and spread systemically via monocytes, challenging previous understanding of their tropism and disease patterns.
DOI 10.1101/2020.04.10.036640