P. Johnson

Immunopeptidomics-guided identification of functional neoantigens in non-small cell lung cancer

The paper identifies functional neoantigens in NSCLC patients using immunopeptidomics, achieving an 83% success rate in eliciting immune responses.

Polyphosphate mobilization influences the ability of Cryptococcus neoformans to cause disease in a murine model of cryptococcosis

This study shows that polyphosphate mobilization is critical for Cryptococcus neoformans virulence in a mouse model, affecting cell surface structure, immune response, and mitochondrial function.

Differential TLR-ERK1/2 activity promotes viral ssRNA and dsRNA mimic-induced dysregulated immunity in macrophages

This study shows that differential TLR-ERK1/2 activity drives dysregulated immunity in macrophages induced by viral RNA mimics.

Evaluation of the potential food allergy risks of recombinant human lactoferrin expressed in Komagataella phaffii

The paper assesses the allergenic risk of recombinant human lactoferrin produced in Komagataella phaffii using bioinformatics, glycan analysis, and simulated digestion, finding low allergenic potential.

Aggressive mimicry lure polymorphisms in the parasitic mussel Lampsilis fasciola model fish or leech host prey and differ in morphology and pigmentation, but not in display behavior.

The paper confirms that Lampsilis fasciola mantle lure polymorphism is a true genetic polymorphism, identifies its ecological targets, and shows that lure morphs have similar display behaviors.

The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis

This study identifies LARP4A and LARP4B as pro-tumorigenic RNA-binding proteins that promote sarcoma and carcinoma growth and metastasis through cell cycle regulation.

Influence of pump laser fluence on ultrafast structural changes in myoglobin

This study shows that varying pump laser fluence in TR-SFX experiments affects structural dynamics and coherent oscillations in myoglobin, highlighting the need for linear photoexcitation in ultrafast studies.

Identification of neoantigens in esophageal adenocarcinoma

This study identifies neoantigens in esophageal adenocarcinoma, finding one directly presented HLA-I neoantigen and a predicted HLA-II neoantigen with T-cell responses, highlighting challenges in neoantigen detection.

Multiple lines of evidence indicate survival of the Ivory-billed Woodpecker in Louisiana

The paper presents trail camera photos and drone videos suggesting the continued presence of Ivory-billed Woodpeckers in Louisiana, challenging the proposed extinction status.

Ion currents through Kir potassium channels are gated by anionic lipids.

The paper shows anionic lipids gate potassium conduction through Kir channels by interacting with the internal gate via fatty acyl tails.

The immunophilin protein FKBPL and its peptide derivatives are novel regulators of vascular integrity and inflammation via NF-kappaB signaling

This paper identifies FKBPL and its peptides as regulators of vascular integrity and inflammation via NF-kappaB signaling, showing therapeutic potential in inflammatory diseases.

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

This study shows that inhibiting KDM5 demethylases restores H3K4 methylation and reactivates genes in KMT2D mutant lymphomas, offering a potential therapeutic strategy.

Sorcin stimulates Activation Transcription Factor 6α (ATF6) transcriptional activity

This study shows that sorcin enhances ATF6 transcriptional activity, which is reduced during lipotoxic stress and contributes to beta cell failure in type 2 diabetes.

RNA sequencing and lipidomic analysis of alveolar macrophages from normal and CD44 deficient mice

This study shows CD44 deficiency in mice leads to impaired alveolar macrophage lipid homeostasis, increased surfactant lipids, and exacerbated lung inflammation.

Does skin surface temperature variation account for Buruli ulcer lesion distribution?

This study investigates whether skin surface temperature variation explains Buruli ulcer lesion distribution, finding a weak inverse correlation between cooler skin temperatures and higher lesion incidence.

Co-exposure to multiple Ranavirus types enhances viral infectivity and replication in a larval amphibian system

This study shows that co-exposure to multiple Ranavirus types increases viral infectivity and replication in larval amphibians, leading to larger epizootics.