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This study identifies GCNA as a histone chaperone essential for maintaining spermatogonial stem cells in mice, linking its function to male fertility.

This study shows that thyroid hormone deficiency causes anorexia during hibernation in ground squirrels by inhibiting hypothalamic feeding center sensitivity to hunger signals.

This study shows that methionine restriction during early adulthood extends lifespan in Drosophila by reducing oxidatively-damaged methionine through MsrA induction.

This study tests a simple phenomenological muscle model to predict eccentric contraction mechanics, finding preliminary support for its potential.

This study shows ATF4 is essential for cold-induced thermogenesis in mice through amino acid metabolism, independent of FGF21, while FGF21 is not required for thermoregulation.

This study uses computational models to show that distinct sodium channel subpopulations with different biophysical properties and locations affect cardiac conduction speed and robustness.

This study shows sub-clinical variations in free T3 levels are linked to health, demographic, and socioeconomic outcomes, suggesting T3 is a key factor connecting biology and socio-economic factors.

This study identifies abnormal ENS activity in HSCR mouse models, linking it to post-surgical motor dysfunction and suggesting functional ENS defects beyond aganglionosis.

This study shows high salt diet impairs kidney microvascular NO signaling in rats through endothelial HDAC1 activation mediated by a humoral factor.

This study shows LRRC8A anion channels interact with MPRIP to regulate vascular relaxation and inflammation through redox-dependent cytoskeletal changes.

This study uses contrast-enhanced microCT to visualize vasculature in bone and peri-implant tissues across animal models, demonstrating dual-energy imaging for distinguishing bone from contrast agents.

This study investigates NMJ destabilization and activity-dependent signaling deregulation in DM1 mouse models, identifying CaMKII and HDAC4 as key factors in synaptic gene expression and muscle dysfunction.

This study shows MK2 deficiency reduces mortality and alters cytokine levels during the inflammatory phase after myocardial infarction in mice.

This study compares osmoregulatory strategies and gill ion transporter gene expression in two Sub-Antarctic crabs, revealing interspecific differences in salinity tolerance and gene regulation.

This study shows that BMP signaling in the pharynx of C. elegans coordinates anti-microbial peptide expression and pharyngeal pumping to enhance survival against bacterial pathogens.

This study shows that vitamin D signaling regulates skeletal muscle fuel choice, affecting metabolic flexibility and insulin response to different diets.

The paper investigates whether haploinsufficiency from protein-null ATP1A1 variants causes disease, finding that Atp1a1+/- mice are phenotypically normal and a human with a null variant shows no disease features.

The paper investigates how subjective sleep onset latency relates to sleep structure, body heat loss, and temperature changes in healthy adults, finding that heat dissipation before sleep significantly predicts perceived sleep latency.

This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.