S. Hall

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Utility of long-read sequencing for All of Us

The paper compares short-read and long-read sequencing in the All of Us initiative, finding HiFi reads provide the most accurate variant calling and presents a cloud-based pipeline for long-read analysis.

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

Vascular Smooth Muscle Cell Mechanotransduction Through Serum and Glucocorticoid Inducible Kinase-1 Promotes Interleukin-6 Production and Macrophage Accumulation in Murine Hypertension

This study shows that SGK-1 in vascular smooth muscle cells promotes IL-6 and macrophage accumulation in hypertension via mechanotransduction and AngII signaling.

Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip

This study uses a human lung alveolus-on-a-chip to show that HMOX-1 mediates acute radiation-induced lung injury and that its activation reduces early injury but worsens later damage.

The potentiative cytotoxic effect of IGF1R and EGFR inhibition on the Head and Neck Cancer Proteome

This study investigates the combined effect of IGF1R and EGFR inhibitors on HNSCC proteome, showing enhanced inhibition of receptor tyrosine kinase signaling through pathway analysis.

Direct RNA sequencing of Respiratory Syncytial Virus infected human cells generates a detailed overview of RSV polycistronic mRNA and transcript abundance

This study uses direct RNA sequencing to analyze RSV mRNA transcripts in infected cells, revealing gene abundance patterns and polyadenylate tail lengths.

Prioritising the eradication of invasive species from island archipelagos with high reinvasion risk

This paper develops a prioritization method for island invasive species eradication that accounts for reinvasion risk, showing it improves conservation outcomes in case studies.

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

Local adaptations of Mediterranean sheep and goats through an integrative approach

This study identifies genes underlying local adaptations in Mediterranean sheep and goats using historical and environmental context with new methodology.

Impact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition

This study shows how changes in individual glycan units of HIV-1 Env affect structure, function, and antibody recognition through high-resolution glycomics and molecular dynamics.

Can hot temperatures limit disease transmission? A test of mechanisms in a zooplankton-fungus system

The paper tests how high temperatures affect disease transmission in a zooplankton-fungus system, finding that while hot temperatures constrain transmission, they do not fully explain the absence of summer epidemics.