PhysiologybioRxivPreprint
The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK
C. Chen, B. Lomenick, M. Chai…·J. Huang
This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.
DOI 10.1101/2022.10.10.511641