Author

J. A. Loo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 6 Organism:C. elegans· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

A. K. Goring· 2 shared H. H. Nguyen· 2 shared J. M. Muroski· 2 shared J. Y. Fu· 2 shared R. R. Ogorzalek Loo· 2 shared R. T. Clubb· 2 shared Y. Chen· 2 shared A. A. Vashisht· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. K. Goring

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The exoproteome and surfaceome of toxigenic Corynebacterium diphtheriae 1737 and its response to iron-restriction and growth on human hemoglobin

A. K. Goring, S. T. Hale, P. Dasika, Y. Chen, R. T. Clubb, J. A. Loo

This study identifies iron-dependent changes in the exoproteome and surfaceome of C. diphtheriae 1737, revealing virulence factors involved in heme acquisition and host interaction.

bioRxiv · May 19, 2024 · PreprintBiochemistry

mTORC2 Interactome and Localization Determine Aggressiveness of High-Grade Glioma Cells through Association with Gelsolin

N. Chantaravisoot, P. Wongkongkathep, N. Kalpongnukul, N. Pacharakullanon, P. Kaewsapsak, C. Ariyachet, J. A. Loo, F. Tamanoi, T. Pisitkun

This study identifies mTORC2 interactome changes and highlights Gelsolin's role in mTORC2-mediated cell migration in high-grade glioma.

bioRxiv · Oct 12, 2022 · PreprintCancer Biology

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

C. Chen, B. Lomenick, M. Chai, W. Huang, J. Chu, L. Vergnes, R. O. Johnson, A. A. Vashisht, R. M. Chin, M. M. Dix, G. Simon, X. Fu, J. C. Link, H. Hwang, X. Yin, , J. Huang

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

bioRxiv · Oct 10, 2022 · PreprintPhysiology

Dynamic acylome reveals metabolite driven modifications in Syntrophomonas wolfei

J. Y. Fu, J. M. Muroski, M. A. Arbing, J. A. Salguero, N. Q. Wofford, M. J. McInerney, R. P. Gunsalus, J. A. Loo, R. R. O. Loo

The paper identifies acyl-lysine modifications in S. wolfei proteins linked to fatty acid degradation pathways using mass spectrometry-based proteomics.

bioRxiv · Jul 18, 2022Microbiology

Secreted and cell surface proteome analysis of pathogenic Corynebacterium diphtheriae reveals proteins relevant to virulence

A. K. Goring, Y. Chen, R. T. Clubb, J. A. Loo

This study identifies over three times more proteins from secreted and cell-surface proteomes of C. diphtheriae than previous studies, revealing virulence-related proteins and iron-regulated pathways.

bioRxiv · Sep 6, 2020 · PreprintMicrobiology

Leveraging immonium ions for identifying and targeting acyl-lysine modifications in proteomic datasets

J. M. Muroski, J. Y. Fu, H. H. Nguyen, R. R. Ogorzalek Loo, J. A. Loo

This paper introduces a method using immonium ions to identify acyl-lysine modifications in proteomic datasets, demonstrating their utility in detecting and validating these modifications.

bioRxiv · Apr 20, 2020Biochemistry

Characterization of protein-ligand binding interactions of enoyl-ACP reductase (FabI) by native MS reveals allosteric effects of coenzymes and the inhibitor triclosan

P. M. Joyner, D. P. Tran, M. A. Zenaidee, J. A. Loo

This study uses native mass spectrometry to analyze protein-ligand interactions of FabI, revealing allosteric effects of coenzymes and triclosan.

bioRxiv · Dec 30, 2019Biochemistry

N-terminal autoprocessing and acetylation of MARTX Makes-Caterpillars Floppy-like effector is stimulated by ADP-Ribosylation Factor 1 in advance of Golgi fragmentation

A. Herrera, J. Muroski, R. Sengupta, H. H. Nguyen, S. Agarwal, R. R. Ogorzalek Loo, S. Mattoo, J. A. Loo, K. J. F. Satchell

This study identifies ARF1 and ARF3 as activators of MCF autoprocessing and shows that MCF acetylation and Golgi fragmentation contribute to cytotoxicity.

bioRxiv · Aug 28, 2019Microbiology