Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets
Q. Tang, M. T. Villar, A. Artigues, J. P. Thyfault, U. Apte, H. Zhu, K. R. Peterson, A. W. Fenton
The paper identifies point mutations that mimic allosteric effectors in human liver pyruvate kinase to validate potential drug targets for treating diabetes.
bioRxiv · May 9, 2019Biochemistry