J. P. Thyfault

Disruption of Hepatic Mitochondrial Pyruvate and Amino Acid Metabolism Impairs Gluconeogenesis and Endurance Exercise Capacity in Mice

Exposure to early life stress impairs weight loss maintenance success in mice.

This study shows that early life stress impairs weight loss maintenance in mice, with greater weight regain and adiposity in stressed mice, and exercise benefits vary by sex and diet.

Early life stress exposure increases susceptibility to high fat/high sucrose diet in female mice

This study shows that early life stress increases female mice's susceptibility to metabolic dysfunction and pain when exposed to a high-fat/high-sucrose diet.

Reduced Liver-Specific PGC1a Increases Susceptibility for Short-Term Diet-induced Weight Gain in Male Mice

This study shows that reduced liver-specific PGC1a in male mice increases diet-induced weight gain and energy imbalance, but not in females, and that vagal signaling affects this effect in wildtype but not in PGC1a-deficient mice.

A high fat anti-inflammatory diet improves widespread allodynia despite worsening metabolic outcomes in adult mice exposed to neonatal maternal separation

Early life stress reduces voluntary exercise and its prevention of diet-induced obesity and metabolic dysfunction in mice

Divergent Energy Expenditure Impacts Mouse Metabolic Adaptation to Acute High-Fat/High-Sucrose Diet Producing Sexually Dimorphic Weight Gain Patterns

This study shows that differences in energy expenditure due to ambient temperature and sex affect metabolic adaptation to a high-fat/high-sucrose diet, leading to sexually dimorphic weight gain patterns in mice.

Mutational mimics of allosteric effectors: a genome editing design to validate allosteric drug targets

The paper identifies point mutations that mimic allosteric effectors in human liver pyruvate kinase to validate potential drug targets for treating diabetes.

Hepatocyte-Specific Hepatocyte Nuclear Factor 4 alpha (HNF4α) Deletion Decreases Resting Energy Expenditure By Disrupting Lipid and Carbohydrate Homeostasis

This study shows that deleting HNF4α in hepatocytes reduces resting energy expenditure by disrupting lipid and carbohydrate homeostasis in mice.