Author

A. Blake

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:ecology & biodiversity· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Assay:imaging· 1

Frequent Co-Authors

C. Verrill· 2 shared T. Maughan· 2 shared A. A. Meade· 1 shared A. Burns· 1 shared A. Chatzipli· 1 shared A. D. Beggs· 1 shared A. G. Abraham· 1 shared A. Hubert· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

C. Verrill

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Scaling use of the rust fungus Puccinia punctiformis for biological control of Canada thistle (Cirsium arvense (L.) Scop.): First report on a U.S. statewide effort

D. W. Bean, K. Gladem, K. Rosen, A. Blake, R. E. Clark, C. Henderson, J. Kaltenbach, J. Price, E. L. Smallwood, D. K. Berner, S. L. Young, R. N. Schaeffer

This study reports on an 8-year monitoring effort of a biological control program using the rust fungus Puccinia punctiformis to reduce Canada thistle stem densities in Colorado, finding declines linked to environmental factors and inoculum deployment.

bioRxiv · Sep 30, 2023 · PreprintPathology

Copepod life history evolution under high and low food regimes

A. Blake, D. Marshall

This study investigates how food regime changes affect copepod life history evolution, finding shifts in body size, fecundity, and offspring investment strategies over generations.

bioRxiv · Dec 9, 2022Evolutionary Biology

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

M. Eyres, S. Lanfredini, A. Burns, A. Blake, F. Willenbrock, R. Goldin, D. Hughes, S. Hughes, A. Thapa, D. Valoulis, A. Hubert, Z. D'Costa, A. Sabbagh, A. G. Abraham, C. Blancher, , E. O'Neill

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

bioRxiv · Oct 22, 2020Cancer Biology

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

K. Sirinukunwattana, E. Domingo, S. Richman, K. L. Redmond, A. Blake, C. Verrill, S. J. Leedham, A. Chatzipli, C. Hardy, C. Whalley, C.-H. Wu, A. D. Beggs, U. McDermott, P. Dunne, A. A. Meade, , V. Koelzer

This paper develops imCMS, a deep learning method to classify colorectal cancer subtypes from histological images, showing improved accuracy over bioinformatic methods.

bioRxiv · May 23, 2019Cancer Biology