C. Hardy

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

This paper introduces ADT-007, a novel pan-RAS inhibitor that effectively blocks tumor growth in mouse models of GI cancer by targeting RAS activation and inducing apoptosis.

How often are male mosquitoes attracted to humans?

This study investigates how often male mosquitoes are attracted to humans through literature review, field trials, and lab experiments, finding attraction is limited to specific species and can be repelled by repellents.

Base editing screens map mutations affecting IFNγ signalling in cancer

This study uses base editing to identify mutations affecting IFNγ signalling in cancer, revealing loss- and gain-of-function variants with clinical relevance.

The longitudinal dynamics and natural history of clonal haematopoiesis

This study tracks clonal haematopoiesis clones over time, finding that mutation type influences growth rates and malignant risk.

Immunohistochemical assays for bladder cancer molecular subtyping: Optimizing parsimony and performance using Lund taxonomy

The paper develops and validates simple immunohistochemical classifiers for bladder cancer subtyping using routine and non-routine antibody assays, achieving high accuracy in identifying molecular subtypes.

Sexual dimorphism in outcomes of non-muscle invasive bladder cancer: a role of CD163+ M2 macrophages, B cells and PD-L1 immune checkpoint.

This study identifies sexual dimorphism in NMIBC immune microenvironment, showing higher CD163+ macrophages and PD-L1 in female tumors, linked to worse recurrence-free survival.

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

This paper develops imCMS, a deep learning method to classify colorectal cancer subtypes from histological images, showing improved accuracy over bioinformatic methods.