A. Burns

A Rapid in vivo Pipeline to Identify Small Molecule Inhibitors of Amyloid Aggregation

This paper presents an in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by screening compounds that suppress crystal formation in C. elegans.

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape

This study engineers SARS-CoV-2 neutralizing antibodies through directed evolution to enhance their potency and reduce viral escape.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

Broadening a SARS-CoV-1 neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

The Mechanism of Vesicle Solubilization by the Detergent Sodium Dodecyl Sulfate

This study investigates the molecular dynamics of vesicle solubilization by SDS using advanced biophysical methods, revealing biphasic kinetics involving vesicle expansion and rapid lipid loss.

Breathing new life into the critical oxygen partial pressure (Pcrit): a new definition, interpretation and method of determination

This paper redefines Pcrit as the oxygen partial pressure at which physiological oxygen supply is maximized, showing it correlates with existing Pcrit values and offers methodological advantages.

Signalome-wide assessment of erythrocyte response to Plasmodium reveals novel targets for host-directed antimalarial intervention

The paper assesses host erythrocyte signaling during Plasmodium infection and identifies c-MET and B-Raf as potential targets for antimalarial intervention.

Calibration and Evaluation of a Force Measurement Glove for Field-Based Monitoring of Manual Wheelchair Users

The paper calibrates and evaluates a force measurement glove to assess upper extremity loading in manual wheelchair users, finding it detects 72.7% of propulsion peaks with strong correlation to instrumented rim measurements.

Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

The diagnostic chronic lymphocytic leukaemia genome by nanopore sequencing

This paper presents a nanopore-based assay for CLL diagnostics, showing it can detect TP53 mutations, del17p13.1, and IgHV status in one run with high accuracy.

Microbial biogeography and ecology of the mouth and implications for periodontal diseases

This paper explores microbial biogeography in the human mouth, linking spatial patterns to periodontal diseases and proposing methods to test hypotheses about subgingival microbiota variation.