Author

C. Weidle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:protein structure· 3 Approach:deep learning· 2 Research Focus:protein design· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Borst· 3 shared D. Baker· 3 shared P. J. Y. Leung· 3 shared A. Broerman· 1 shared A. Courbet· 1 shared A. Idris· 1 shared A. K. Bera· 1 shared A. Kang· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

A. J. Borst

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Atomically accurate de novo design of antibodies with RFdiffusion

N. R. Bennett, J. L. Watson, R. J. Ragotte, A. J. Borst, D. L. See, C. Weidle, R. Biswas, Y. Yu, E. L. Shrock, R. Ault, P. J. Y. Leung, B. Huang, I. Goreshnik, J. Tam, K. D. Carr, , D. Baker

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

bioRxiv · Mar 14, 2024Bioengineering

De novo design of allosterically switchable protein assemblies

A. Pillai, A. Idris, A. Philomin, C. Weidle, R. Skotheim, P. J. Y. Leung, A. Broerman, C. Demakis, A. J. Borst, F. Praetorius, D. Baker

This paper designs allosterically switchable protein assemblies using rigid-body coupling of effector-switchable modules, demonstrating cooperative ligand binding and structural changes similar to natural systems.

bioRxiv · Nov 1, 2023Biochemistry

Blueprinting expandable nanomaterials with standardized protein building blocks

T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, C. Weidle, , D. Baker

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

bioRxiv · Jun 9, 2023Biochemistry

Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection

J. Boonyaratanakornkit, S. Singh, C. Weidle, J. Rodarte, R. Bakthavatsalam, J. Perkins, G. B. E. Stewart-Jones, P. D. Kwong, A. T. McGuire, M. Pancera, J. J. Taylor

The paper identifies a monoclonal antibody, PI3-E12, that neutralizes HPIV3 and provides protection in cotton rats, showing potential for clinical use in both immunocompetent and immunocompromised individuals.

bioRxiv · Jun 15, 2020Immunology