Author

A. C. Boon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1 Organism:virus· 1

Frequent Co-Authors

T. L. Bricker· 4 shared D. Wang· 3 shared A. B. Janowski· 2 shared A. Joshi· 2 shared A. Jung· 2 shared B. A. Parikh· 2 shared B. Febles· 2 shared C. Fujii· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMicrobiology

T. L. Bricker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Serosurveillance and first detection of Bourbon virus RNA in a wildlife host

G. Bamunuarachchi, F. Najera, I. D. Aziati, J. L. Palmer, E. G. Biro, D. Wang, S. L. Deem, A. C. Boon, S. A. Adalsteinsson

The paper detects BRBV RNA in a coyote and identifies seropositive wildlife species in St. Louis, linking tick density and host composition to BRBV exposure.

bioRxiv · Jun 4, 2024Microbiology

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19

A. C. Boon, T. L. Bricker, E. J. Fritch, S. R. Leist, K. L. Gully, R. S. Baric, R. Graham, B. V. Troan, M. Mahoney, J. W. Janetka

This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.

bioRxiv · Feb 9, 2024Microbiology

NVX-CoV2373 ancestral and NVX-CoV2540 BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters

T. L. Bricker, A. Joshi, N. Soudani, S. Scheaffer, N. Patel, M. G. Xabier, G. Smith, M. Diamond, A. C. Boon

This study evaluates the efficacy of NVX-CoV2373 and NVX-CoV2540 nanoparticle vaccines against the Omicron BA.5 variant in Syrian hamsters, showing reduced viral infection and better protection compared to mRNA vaccines.

bioRxiv · Aug 7, 2023Microbiology

The highly conserved stem-loop II motif is dispensable for SARS-CoV-2

H. Jiang, A. Joshi, T. Gan, A. B. Janowski, C. Fujii, T. L. Bricker, T. Darling, H. H. Harastani, K. Seehra, H. Chen, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. Handley, , A. C. Boon

This study shows that the stem-loop II motif in SARS-CoV-2 is not essential for viral growth in vitro or in vivo.

Journal of Virology · Jun 29, 2023Peer-reviewedMicrobiology

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

A. B. Janowski, H. Jiang, C. Fujii, M. C. Owen, T. L. Bricker, T. L. Darling, H. H. Harastani, K. Seehra, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. A. Handley, B. A. Parikh, V. Lulla, , D. Wang

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

bioRxiv · Apr 30, 2022 · PreprintMicrobiology