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9 papers
Recent·Most cited
A. C. Boon, T. L. Bricker, E. J. Fritch, S. R. Leist, K. L. Gully, R. S. Baric, R. Graham, B. V. Troan, M. Mahoney, J. W. Janetka
This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.
bioRxiv · Feb 9, 2024Microbiology
T. L. Bricker, A. Joshi, N. Soudani, S. Scheaffer, N. Patel, M. G. Xabier, G. Smith, M. Diamond, A. C. Boon
This study evaluates the efficacy of NVX-CoV2373 and NVX-CoV2540 nanoparticle vaccines against the Omicron BA.5 variant in Syrian hamsters, showing reduced viral infection and better protection compared to mRNA vaccines.
bioRxiv · Aug 7, 2023Microbiology
H. Jiang, A. Joshi, T. Gan, A. B. Janowski, C. Fujii, T. L. Bricker, T. Darling, H. H. Harastani, K. Seehra, H. Chen, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. Handley, , A. C. Boon
This study shows that the stem-loop II motif in SARS-CoV-2 is not essential for viral growth in vitro or in vivo.
Journal of Virology · Jun 29, 2023Peer-reviewedMicrobiology
B. Ying, T. L. Darling, P. Desai, C.-Y. Liang, I. P. Dmitriev, N. Soudani, T. L. Bricker, E. A. Kashentseva, H. H. Harastani, A. G. Schmidt, D. T. Curiel, A. C. M. Boon, M. S. Diamond
This paper shows a bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 in mice and hamsters through mucosal immunity, despite poor serum neutralizing antibody responses.
bioRxiv · May 4, 2023 · PreprintMicrobiology
J. B. Case, S. M. Scheaffer, T. L. Darling, T. L. Bricker, L. J. Adams, H. H. Harastani, R. Trende, S. Sanapala, D. H. Fremont, A. C. M. Boon, M. S. Diamond
This paper evaluates the pathogenicity of SARS-CoV-2 BQ.1.1 and BA.5.5 variants in multiple rodent models, finding increased virulence in transgenic mice but not in conventional mice or hamsters.
bioRxiv · Apr 28, 2023 · PreprintMicrobiology
A. B. Janowski, H. Jiang, C. Fujii, M. C. Owen, T. L. Bricker, T. L. Darling, H. H. Harastani, K. Seehra, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. A. Handley, B. A. Parikh, V. Lulla, , D. Wang
This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.
bioRxiv · Apr 30, 2022 · PreprintMicrobiology
T. L. Darling, B. Ying, B. Whitener, L. VanBlargan, T. L. Bricker, C.-Y. Liang, A. Joshi, G. Bamunuarachchi, K. Seehra, A. Schmitz, P. Halfmann, Y. Kawaoka, S. Elbashir, D. K. Edwards, L. Thackray, , A. Boon
This study evaluates the efficacy of mRNA-1273 and Ad26.COV2.S vaccines against the B.1.621 variant in mice and hamsters, showing protection against infection and pathology.
bioRxiv · Dec 29, 2021Microbiology
A. J. Schmitz, J. S. Turner, Z. Liu, I. D. Aziati, R. E. Chen, A. Joshi, T. L. Bricker, T. L. Darling, D. C. Adelsberg, W. B. Al Soussi, J. B. Case, T. Lei, M. Thapa, F. Amanat, J. A. O'Halloran, , A. H. Ellebedy
A vaccine-induced human monoclonal antibody neutralizes SARS-CoV-2 and variants, reducing lung inflammation and viral load in hamsters.
bioRxiv · Mar 24, 2021Immunology
J. Son, S. Huang, Q. Zeng, T. L. Bricker, J. B. Case, J. Zhou, R. Zang, Z. Liu, X. Chang, H. H. Harastani, L. Chen, M. F. Gomez Castro, Y. Zhao, H. P. Kohio, G. Hou, , S. Ding
The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.
bioRxiv · Sep 24, 2020Microbiology