Author

V. Lulla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. E. Firth· 2 shared A. S. Nicholson· 2 shared H. Ali· 2 shared H. Stewart· 2 shared J. E. Deane· 2 shared S. C. Graham· 2 shared A. B. Janowski· 1 shared A. C. Boon· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

A. E. Firth

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Author profile →

6 papers

Recent·Most cited

The astrovirus N-terminal nonstructural protein anchors replication complexes to the perinuclear ER membranes

H. Ali, D. Noyvert, J. Hankinson, G. Lindsey, V. Lulla

This study identifies di-arginine motifs in the N-terminal domain of astrovirus nsP1a that mediate ER retention and replication complex formation.

bioRxiv · Jan 9, 2024Microbiology

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

C. Lefevre, G. M. Cook, A. M. Dinan, S. Torii, H. Stewart, G. Gibbons, A. S. Nicholson, L. Echavarria-Consuegra, L. W. Meredith, V. Lulla, J. C. Kenyon, I. G. Goodfellow, J. E. Deane, S. C. Graham, A. Lakatos, , N. Irigoyen

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

H. Stewart, Y. Lu, S. O'Keefe, A. Valpadashi, L. D. Cruz-Zaragoza, H. A. Michel, S. K. Nguyen, G. W. Carnell, N. Lukhovitskaya, R. Milligan, I. Jungreis, V. Lulla, A. D. Davidson, D. A. Matthews, S. High, , A. E. Firth

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

bioRxiv · Nov 15, 2022Microbiology

Attenuation hotspots in neurotropic human astroviruses

H. Ali, A. Lulla, A. S. Nicholson, E. B. Wignall-Fleming, R. L. OConnor, D.-L. Vu, S. C. Graham, J. E. Deane, S. Guix, V. Lulla

This study identifies attenuation hotspots in neurotropic human astroviruses by analyzing dispensable regions in the capsid-coding region and confirms their role in neuronal attenuation using recombinant viruses.

bioRxiv · Sep 6, 2022Microbiology

The highly conserved stem-loop II motif is important for the lifecycle of astroviruses but dispensable for SARS-CoV-2

A. B. Janowski, H. Jiang, C. Fujii, M. C. Owen, T. L. Bricker, T. L. Darling, H. H. Harastani, K. Seehra, S. Tahan, A. Jung, B. Febles, J. A. Blatter, S. A. Handley, B. A. Parikh, V. Lulla, , D. Wang

This study shows the stem-loop II motif is critical for astrovirus replication but not for SARS-CoV-2.

bioRxiv · Apr 30, 2022 · PreprintMicrobiology

A hidden gene in astroviruses encodes a cell-permeabilizing protein involved in virus release

V. Lulla, A. E. Firth

The paper identifies a conserved ORFX gene in astroviruses that encodes a cell-permeabilizing protein, XP, which facilitates virus release and contributes to viral replication and pathogenesis.

bioRxiv · Jun 6, 2019Microbiology