Author

A. Chacinska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

K. Mohanraj· 2 shared P. Rehling· 2 shared R. A. Serwa· 2 shared A. Gosk· 1 shared A. Kodron· 1 shared A. P. Richardson· 1 shared B. H. M. Mussulini· 1 shared B. Warscheid· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

K. Mohanraj

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Protein homeostasis is maintained by proteasomes containing PSMB9 induced by EEF1A2 upon mitochondrial stress

M. Kim, L. Samluk, T. M. Stepkowski, I. Suppanz, R. A. Serwa, A. Kodron, B. Warscheid, A. Chacinska

The paper shows that mitochondrial stress increases proteasome activity via HSPB1 and PSMB9, which are regulated by EEF1A2 and localized near mitochondria to prevent protein aggregation.

bioRxiv · Dec 23, 2021 · PreprintCell Biology

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel metazoan specific complex III assembly factor

K. J. Chojnacka, K. Mohanraj, S. Callegari, B. H. M. Mussulini, P. Elanchelyan, A. Gosk, T. Banach, T. Goral, P. Rehling, R. A. Serwa, A. Chacinska

This study identifies OCIAD2 as a novel metazoan-specific complex III assembly factor, showing its role in mitochondrial function and its deregulation in cancer and neurodegenerative disorders.

bioRxiv · Dec 9, 2020 · PreprintCell Biology

Nutritional status and fecundity are synchronised by muscular exopheresis

M. Turek, M. Piechota, K. Banasiak, N. Shanmugam, M. Macias, M. A. Sliwinska, M. Niklewicz, K. Kowalski, N. Nowak, A. Chacinska, W. Pokrzywa

The paper identifies exophers as muscle-derived vesicles that transfer yolk proteins to embryos, linking nutritional status to fecundity in C. elegans.

bioRxiv · Jun 17, 2020Physiology

A High-Resolution Luminescent Assay For Rapid And Continuous Monitoring Of Protein Translocation Across Biological Membranes

G. C. Pereira, W. J. Allen, D. W. Watkins, L. Buddrus, D. Noone, X. Liu, A. P. Richardson, A. Chacinska, I. Collinson

This paper introduces a high-resolution luminescent assay for rapid and continuous monitoring of protein translocation, demonstrating its application in bacterial and mitochondrial systems.

bioRxiv · Nov 1, 2018Biochemistry

Inhibition of proteasomal degradation rescues a pathogenic variant of mitochondrial Respiratory chain assembly 1 factor

K. Mohanraj, M. Wasilewski, C. Beninca, D. Cysewski, J. Poznanski, P. Sakowska, M. Deckers, S. Dennerlein, E. Fernandez-Vizarra, P. Rehling, M. Dadlez, M. Zeviani, A. Chacinska

This study shows that inhibiting proteasome degradation rescues mutant RESA1 protein function and complex IV activity in patient-derived fibroblasts.

bioRxiv · Jul 24, 2018Biochemistry

Cytosolic ribosomes on the surface of mitochondria

V. A. M. Gold, P. Chroscicki, P. Bragoszewski, A. Chacinska

The paper uses electron cryo-tomography to show ribosomes interacting with the TOM complex on mitochondria, supporting localized translation and spatial coupling of protein synthesis and transport.

The EMBO Reports · Aug 21, 2017Peer-reviewedCell Biology