Author

Z. Arany

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Physiology· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Organism:human· 4 Assay:metabolomics· 4 Research Focus:differential expression· 3 Research Focus:metabolism & bioenergetics· 3 Assay:proteomics· 3

Frequent Co-Authors

C. E. Bowman· 2 shared K. E. Wellen· 2 shared M. D. Neinast· 2 shared N. W. Snyder· 2 shared A. Chatoff· 1 shared A. Hoshino· 1 shared A. K. Rustgi· 1 shared A. Ren· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. E. Bowman

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

C. E. Bowman, M. D. Neinast, C. Jang, J. Patel, M. C. Blair, E. T. Mirek, W. O. Jonsson, Q. Chu, L. Merlo, L. Mandik-Nayak, T. G. Anthony, J. D. Rabinowitz, Z. Arany

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

bioRxiv · Mar 5, 2024Pharmacology & Toxicology

The mitochondrial Ca2+ channel MCU is critical for tumor growth by supporting cell cycle progression and proliferation

E. Fernandez Garcia, U. Paudel, M. C. Noji, C. E. Bowman, J. R. Pitarresi, A. K. Rustgi, K. E. Wellen, Z. Arany, J. S. Weissenrieder, J. K. Foskett

This study shows that the mitochondrial Ca2+ channel MCU supports tumor growth by enabling cell cycle progression and proliferation through mitochondrial Ca2+ uptake, despite unchanged mitochondrial function.

bioRxiv · Apr 26, 2023 · PreprintCancer Biology

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism

I. Soaita, E. Megill, D. Kantner, A. Chatoff, Z. Arany, N. W. Snyder, K. E. Wellen, S. W. Trefely

This study shows that dynamic protein deacetylation in Acly-/- MEFs contributes carbons to acetyl-CoA but only transiently supplies about 9% of cellular acetyl-CoA.

bioRxiv · Dec 28, 2022Biochemistry

CRISPR/Cas9 screens implicate RARA and SPNS1 in doxorubicin cardiotoxicity

W. Lv, Y. Shao, A. Hoshino, Z. Arany, K. Musunuru, C. McDermott-Roe

This study uses CRISPR/Cas9 screens to identify RARA and SPNS1 as genetic modifiers of doxorubicin cardiotoxicity, revealing their roles in cell death and drug accumulation.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

T. Katsuda, H. Cure, K. P. Simeonov, Z. Arany, M. Grompe, B. Stanger

This paper introduces RIME, a method for rapid in vivo gene editing in adult mouse liver, demonstrating efficient knockout of multiple genes.

bioRxiv · Mar 4, 2022Physiology

Prediction and validation of host cleavage targets of SARS-CoV-2 3C like protease

N. Yucel, S. Marchiano, E. Tchelepi, Q. McAfee, N. Nimmagadda, A. Ren, S. Shi, C. E. Murry, Z. Arany

This study predicts and validates host cleavage targets of SARS-CoV-2 3CL protease using bioinformatics and experimental methods, identifying new targets like Obscurin and linking them to cardiac dysfunction in COVID-19.

bioRxiv · Jan 17, 2022 · PreprintMicrobiology

Metabolic and Proteomic Defects in Human Hypertrophic Cardiomyopathy

M. Previs, T. O'Leary, N. Wood, M. Morley, B. Palmer, M. LeWinter, J. Yob, F. Pagani, C. Petucci, M. S. Kim, K. Margulies, Z. Arany, D. Kelly, S. Day

This study identifies metabolic and proteomic defects in human hypertrophic cardiomyopathy, showing depletion of fatty acid derivatives and increased alternate fuel metabolites.

bioRxiv · Aug 18, 2021 · PreprintPhysiology

Direct anabolic three carbon metabolism via propionate to a six carbon metabolite occurs in human heart and in vivo across mouse tissues

M. T. Doan, M. D. Neinast, E. L. Varner, K. Bedi, D. Bartee, H. Jiang, S. Trefely, P. Xu, J. P. Singh, C. Jiang, E. Rame, D. Brady, J. L. Meier, K. Marguiles, Z. Arany, N. W. Snyder

The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.

bioRxiv · Jun 15, 2020 · PreprintBiochemistry