E. Megill

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

Lactoylglutathione promotes inflammatory signaling in macrophages

This study shows that lactoylglutathione (LGSH) promotes inflammatory signaling in macrophages by increasing histone lactoylation and chromatin accessibility.

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

Comparison of colorimetric, fluorometric, and liquid chromatography-mass spectrometry assays for acetyl-coenzyme A

The paper compares colorimetric, fluorometric, and LC-MS-based assays for measuring acetyl-CoA, finding that LC-MS/MS and LC-HRMS provide reliable results with internal standards, while colorimetric ELISA fails even with standards.

Dynamic protein deacetylation is a limited carbon source for acetyl-CoA-dependent metabolism

This study shows that dynamic protein deacetylation in Acly-/- MEFs contributes carbons to acetyl-CoA but only transiently supplies about 9% of cellular acetyl-CoA.