J. Patterson

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

An ECM scaffold combined with a compliant 3D printed spring-shaped reinforcement for cartilage engineering applications

This study develops a dynamic scaffold for cartilage engineering using a 3D printed coil-shaped reinforcement combined with an extracellular matrix slurry to improve mechanical properties and tissue regeneration potential.

A Modified BPaL Regimen for Tuberculosis Treatment replaces Linezolid with Inhaled Spectinamides

This paper evaluates a modified BPaL regimen replacing linezolid with inhaled spectinamide 1599 for tuberculosis treatment, showing similar efficacy while avoiding linezolid-associated adverse events.

Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity reduces lung inflammation

This study treats SARS-CoV-2 infected macaques with high-titer convalescent plasma, showing reduced lung inflammation without affecting virus replication.

Cation and anion channelrhodopsins: Sequence motifs and taxonomic distribution

The paper identifies and characterizes sequence motifs and ion selectivity mechanisms in channelrhodopsins from diverse algal and protist species using electrophysiological analysis and genomic data.

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice

This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.

Novel IRE1-dependent proinflammatory signaling controls tumor infiltration by myeloid cells.

This study identifies an IRE1-dependent proinflammatory signaling pathway in glioblastoma that promotes tumor invasion, angiogenesis, and myeloid cell infiltration.

Independent evolution of cutaneous lymphoma subclones in different microenvironments of the skin

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma

This study identifies branched evolutionary patterns and intratumoral heterogeneity in mycosis fungoides, revealing complex clonal substructures and their implications for treatment resistance.

Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma

This study identifies multiple neoplastic T-cell clones in MF lesions and peripheral blood, suggesting they continuously replenish lesions and contribute to tumor heterogeneity.

Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome Sequencing

This study uses whole exome and transcriptome sequencing to analyze TCR clonality in mycosis fungoides, revealing multiple clonotypes in half of the samples, suggesting malignant transformation occurs at an early progenitor stage.

Experimental Zika Virus Infection in a New World Monkey Model Reproduces Key Features of the Human Disease

This study infects marmosets with Zika virus and finds they exhibit key features of human disease, including asymptomatic infection and viral persistence in lymph nodes.