A. E. Brown

Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

This study creates and phenotypes C. elegans models of Mendelian diseases to enable drug repurposing through high-throughput imaging and screening.

A drug repurposing screen for whipworms informed by comparative genomics

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

Megapixel camera arrays for high-resolution animal tracking in multiwell plates

This paper introduces a high-resolution imaging system for tracking small animals in multiwell plates, enabling detailed behavioral analysis at scale.

Quantitative Behavioural Phenotyping to Investigate Anaesthesia-Induced Neurobehavioural Impairment

This study uses C. elegans to quantify behavioural and morphological changes caused by anaesthetics, finding that isoflurane and ketamine combinations cause impairment, while lithium can rescue it.

Shared behavioral mechanisms underlie C. elegans aggregation and swarming

This study identifies behavioral rules in C. elegans that underlie both aggregation and swarming through quantitative analysis and agent-based modeling.

An open source platform for analyzing and sharing worm behavior data

The paper introduces an open-source platform for analyzing and sharing worm behavior data to address challenges in storage, data formatting, and software for computational ethology.

2,4-Diaminothienopyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

This paper identifies a new class of anthelmintic compounds, DATPs, effective against whipworm adult and egg stages, suggesting potential for environmental control strategies.

Ethology as a physical science

This paper reviews advances in imaging and data analysis that enable quantitative study of animal behavior, aiming to develop unifying principles and theories of behavior.

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

The paper develops an automated system for screening chemical libraries against nematodes, identifying known and novel anthelmintic compounds.