C. Brandt

Integrated organismal responses induced by ecologically-relevant pCO2 and temperature exposures in developing lake sturgeon

This study examines how rising CO2 and temperature affect lake sturgeon development, finding altered transcriptional patterns and reduced metabolic rates under combined stressors.

A drug repurposing screen for whipworms informed by comparative genomics

This paper identifies potential anti-whipworm drugs by testing approved human drugs ex vivo and in vivo, finding limited efficacy due to pharmacokinetic challenges.

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

Nanopore-based enrichment of antimicrobial resistance genes -- a case study

This study evaluates adaptive nanopore sequencing for detecting antimicrobial resistance genes in clinical isolates, showing its effectiveness compared to standard methods.

Context-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae

The paper identifies hidden transmission of a carbapenemase-producing Klebsiella pneumoniae strain using genomic and metagenomic data from multiple studies.

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

Chromosome-level genome assembly and transcriptome- based annotation of the oleaginous yeast Rhodotorula toruloides CBS 14

This paper presents a chromosome-level genome assembly and transcriptome-based annotation of Rhodotorula toruloides CBS 14, identifying a potential plasmid and annotating genes and transcripts.

Novel gut pathobionts confound results in a widely used mouse model of human inflammatory disease

The paper identifies two novel gut bacteria that influence disease variability in a mouse model of inflammatory bowel disease.

SARS-CoV-2 causes severe alveolar inflammation and barrier dysfunction

This study shows SARS-CoV-2 infects alveolar epithelial cells, causing inflammation and barrier dysfunction, while endothelial cells are damaged through cytokine release from infected epithelial cells.

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

Interferon-induced Protein-44 and Interferon-induced Protein 44-like restrict replication of Respiratory Syncytial Virus

This study shows that IFI44 and IFI44L restrict RSV replication and are anti-viral and anti-proliferative, with IFI44L serving as a diagnostic marker for viral infection.

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.