Microglia mediate the early-life programming of adult glucose control
M. Valdearcos, E. R. McGrath, S. Brown Mayfield, A. Folick, R. T. Cheang, L. Li, T. P. Bachor, R. N. Lippert, A. W. Xu, S. K. Koliwad
This study shows that microglia in the mediobasal hypothalamus prune synapses during early life, influencing adult glucose control through perineuronal net refinement.
bioRxiv · Jul 2, 2024Physiology