Cancer BiologybioRxiv
Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
A. Melnick, S. Liang, Y. Liu…·M. Y. Chiang
This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.
DOI 10.1182/blood.2023020144