Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress
A. Melnick, S. Liang, Y. Liu, Q. Wang, N. Dean, E. Choe, N. Kunnath, G. Bodanapu, C. Mullin, F. Akter, K. Lin, B. Magnuson, S. Kumar, D. B. Lombard, A. G. Muntean, , M. Y. Chiang
This study identifies Cdc73 as a Notch cofactor that protects T-ALL cells from DNA damage and mitochondrial stress by intersecting with Notch at chromatin to activate oncogenes and repair pathways.
bioRxiv · Jan 22, 2023Cancer Biology