Author

A. H. de Wilde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:protein structure· 1 Organism:rat· 1

Frequent Co-Authors

E. J. Snijder· 4 shared A. W. M. de Jong· 2 shared D. H. Barouch· 2 shared F. Wegmann· 2 shared H. Schuitemaker· 2 shared J. Custers· 2 shared J. E. M. van der Lubbe· 2 shared M. Barcena· 2 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

E. J. Snijder

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ImmunologybioRxivNov 17, 2020

Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques

L. Solforosi, H. Kuipers, S. K. Rosendahl Huber…·R. C. Zahn

This study evaluates one- and two-dose regimens of the Ad26.COV2.S vaccine in rhesus macaques, showing higher antibody responses with two doses and protection against SARS-CoV-2 in aged animals.

DOI 10.1084/jem.20202756

ratexperimental assay

𝕏 PostBluesky

ImmunologybioRxivJul 30, 2020

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R. Bos, L. Rutten, J. E. M. van der Lubbe…·H. Schuitemaker

This paper evaluates a prefusion-stabilized SARS-CoV-2 Spike protein vaccine candidate, Ad26.COV2.S, showing potent neutralizing and Th1-polarized immune responses in mice.

DOI 10.1038/s41541-020-00243-x

mouseprotein structure

𝕏 PostBluesky

MicrobiologybioRxivMar 24, 2020

A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis

E. J. Snijder, R. W. A. L. Limpens, A. H. de Wilde…·M. Barcena

This study identifies double-membrane vesicles (DMVs) as the central site for viral RNA synthesis in coronaviruses, providing a unifying model of the replication organelle.

DOI 10.1371/journal.pbio.3000715

electronic health recordsexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivMar 24, 2019

Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits

A. H. De Wilde, L. Boomaars-van der Zanden, A. W. M. de Jong…·C. C. Posthuma

This study identifies adaptive mutations in nsp2 and nsp5 of equine arteritis virus that confer resistance to cyclophilin inhibitors, revealing their role in the mechanism of action of these antiviral compounds.

DOI 10.1128/jvi.00490-19

experimental assayhost-pathogen & immune response

𝕏 PostBluesky