Author

R. C. Zahn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:protein structure· 2 Organism:rat· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

H. Schuitemaker· 5 shared D. H. Barouch· 4 shared F. Wegmann· 4 shared E. J. Snijder· 3 shared J. E. M. van der Lubbe· 3 shared L. van der Fits· 3 shared M. Kikkert· 3 shared S. K. Myeni· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersImmunology

H. Schuitemaker

Mutual co-authors in cluster

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5 papers

Recent·Most cited

ImmunologybioRxivSep 23, 2022

Combination Ad26.RSV.preF/RSV preF protein vaccine induces superior humoral, cellular, and protective immunity compared with individual vaccine components in preclinical models

E. Saeland, L. van der Fits, R. Bolder…·R. C. Zahn

This study shows that combining Ad26.RSV.preF and RSV preF protein vaccine components enhances humoral, cellular, and protective immunity compared to using each component alone in preclinical models.

DOI 10.1038/s41541-023-00637-7

mouseArabidopsis

𝕏 PostBluesky

ImmunologybioRxivJan 27, 2021

Low-Dose Ad26.COV2.S Protection Against SARS-CoV-2 Challenge in Rhesus Macaques

X. He, A. Chandrashekar, R. C. Zahn…·D. H. Barouch

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

DOI 10.1016/j.cell.2021.05.040

ratexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintJan 8, 2021

Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing

J. E. M. van der Lubbe, S. K. Rosendahl Huber, A. Vijayan…·F. Wegmann

This study shows that a single dose of Ad26.COV2.S vaccine protects Syrian hamsters from G614 SARS-CoV-2 infection and prevents VAERD even with suboptimal immunity.

DOI 10.1101/2021.01.08.425915

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivNov 17, 2020

Immunogenicity and protective efficacy of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques

L. Solforosi, H. Kuipers, S. K. Rosendahl Huber…·R. C. Zahn

This study evaluates one- and two-dose regimens of the Ad26.COV2.S vaccine in rhesus macaques, showing higher antibody responses with two doses and protection against SARS-CoV-2 in aged animals.

DOI 10.1084/jem.20202756

ratexperimental assay

𝕏 PostBluesky

ImmunologybioRxivJul 30, 2020

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R. Bos, L. Rutten, J. E. M. van der Lubbe…·H. Schuitemaker

This paper evaluates a prefusion-stabilized SARS-CoV-2 Spike protein vaccine candidate, Ad26.COV2.S, showing potent neutralizing and Th1-polarized immune responses in mice.

DOI 10.1038/s41541-020-00243-x

mouseprotein structure

𝕏 PostBluesky