A. H. Meijer

This study screens kinase inhibitors to identify host-directed therapies effective against intracellular bacteria Salmonella Typhimurium and Mycobacterium tuberculosis.

This study shows DRAM1 facilitates antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages by promoting vesicle acidification and fusion.

This study develops a zebrafish transgenic model to investigate anti-inflammatory signaling, showing arginase 2 is expressed in neutrophils during immune challenges.

This study shows that Vibrio cholerae undergoes morphological changes during environmental transitions, which are critical for its ability to colonize host tissues.

This study shows Dram1 enhances resistance to Salmonella infection by promoting LAP, a phagocytic autophagy mechanism, through ROS production and xenophagy.

This study shows glucocorticoids reduce macrophage phagocytosis, increasing bacterial burden in a zebrafish tuberculosis model, which may explain increased susceptibility to tuberculosis in humans.

This study uses RNA-seq to analyze tlr2 mutant zebrafish and finds TLR2 plays a role in transcriptional control, metabolism, and defense against Mycobacterium marinum.

The study shows that Cxcr3.3, an atypical chemokine receptor in zebrafish, regulates macrophage migration by scavenging ligands that would otherwise activate Cxcr3.2, a conventional receptor involved in immune response.

This study shows that S. aureus uses autophagy to create an intracellular niche in neutrophils, while p62-mediated autophagy protects the host.

The paper identifies cxcl11aa as a marker of M1 macrophage polarization in zebrafish during mycobacterial infection using RNAseq profiling of sorted immune cell populations.

The paper shows glucocorticoids inhibit macrophage differentiation to a pro-inflammatory phenotype but not their migration in a zebrafish wound model.

This study shows that Optineurin and p62 are required for autophagic host defense against mycobacterial infection in zebrafish.

The paper shows that Hif-1alpha increases Il-1beta expression in zebrafish macrophages, enhancing nitric oxide production and protecting against Mycobacterium marinum infection.