M. Varela

Trajectory analysis of hepatic stellate cell differentiation reveals metabolic regulation of cell commitment and fibrosis

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms

This study identifies human α-cell and β-cell subtypes and trajectories using integrated scRNA-seq and snRNA-seq, revealing gene signatures for interconversion and highlighting in vivo transitions in T2D.

DRAM1 promotes antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages

This study shows DRAM1 facilitates antibacterial autophagy and lysosomal delivery of Mycobacterium marinum in macrophages by promoting vesicle acidification and fusion.

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma

This study evaluates CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma, finding they reduce tumor growth and improve survival by inducing cell cycle arrest and senescence.

TRIM69 inhibits Vesicular Stomatitis Indiana Virus (VSIV)

This study identifies TRIM69 as an interferon-induced gene that potently inhibits VSIV, with specific antiviral activity and evolutionary signatures of positive selection.

Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages

This study shows that Dram1 deficiency in zebrafish increases susceptibility to Mycobacterium marinum infection by impairing phagosome maturation and inducing pyroptotic cell death in macrophages.

Extracellular mycobacterial DNA drives disease progression by triggering Caspase-11-dependent pyroptosis of infected macrophages

The paper shows extracellular mycobacterial DNA triggers Caspase-11-dependent pyroptosis in macrophages, promoting TB progression through an Asc-independent pathway.

The selective autophagy receptors Optineurin and p62 are both required for innate host defense against mycobacterial infection

This study shows that Optineurin and p62 are required for autophagic host defense against mycobacterial infection in zebrafish.