Chrysin directing an enhanced solubility through the formation of a supramolecular cyclodextrin-calixarene drug delivery system: a potential strategy in antifibrotic diabetes therapeutics
A. Hermenean, E. Dossi, A. Hamilton, M. C. Trotta, M. Russo, C. C. Lepre, C. Sajtos, A. Rusznyak, J. Varadi, I. Bacskay, I. Budai, M. DAmico, F. Fenyvesi
This paper develops a ternary complex of chrysin, OTX008, and SBECD to enhance solubility and delivery of antifibrotic agents for diabetes, showing improved solubility and biocompatibility.
bioRxiv · Oct 3, 2023Pharmacology & Toxicology