Author

A. Hope

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 3 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:ecology & biodiversity· 2 Approach:experimental assay· 2 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

S. J. Torr· 3 shared I. Tirados· 2 shared M. C. Stanton· 2 shared M. J. Lehane· 2 shared P. G. Wyatt· 2 shared R. Selby· 2 shared A. Mugenyi· 1 shared A.-P. Petit· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersEcology

S. J. Torr

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Impact of a national tsetse control programme to eliminate Gambian sleeping sickness in Uganda: a spatio-temporal modelling study.

J. Longbottom, J. Esterhuizen, A. Hope, M. J. Lehane, C. T. Mangwiro, A. Mugenyi, S. Dunkley, R. Selby, I. Tirados, S. J. Torr, M. C. Stanton

This study evaluates the impact of a national tsetse control program using Tiny Targets in Uganda, showing reduced tsetse abundance and low population levels across 4000 km2.

bioRxiv · Feb 16, 2024 · PreprintEcology

Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments

S. Lang, D. A. Fletcher, A.-P. Petit, N. Luise, P. K. Fyfe, F. Zuccotto, D. Porter, A. Hope, F. Bellany, C. Kerr, C. J. MacKenzie, P. G. Wyatt, D. W. Gray

The paper uses NMR and crystallography to identify and assess new HIV-CA binding fragments, leading to the discovery of two compounds with improved binding properties.

bioRxiv · Dec 1, 2023Pharmacology & Toxicology

Modelled impact of Tiny Targets on the distribution and abundance of riverine tsetse

G. A. Vale, J. W. Hargrove, A. Hope, S. J. Torr

The paper models the impact of Tiny Targets on tsetse fly populations in NW Uganda, showing good control despite target degradation and highlighting the need to address reinvasion and seasonality.

bioRxiv · Aug 9, 2023Ecology

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

L. Armstrong, S. M. Lange, V. de Cesare, S. P. Matthews, R. S. Nirujogi, I. Cole, A. Hope, F. Cunningham, R. Toth, R. Mukherjee, D. Bojkova, F. Gruber, D. Gray, P. G. Wyatt, J. Cinatl, , Y. Kulathu

This study characterizes Nsp3 protease activity from SARS-CoV-2 and identifies nanobodies that inhibit PLpro with nanomolar affinity.

bioRxiv · Dec 9, 2020Biochemistry

Impact of Tiny Targets on Glossina fuscipes quanzensis, the primary vector of Human African Trypanosomiasis in the Democratic Republic of Congo.

I. Tirados, A. Hope, R. Selby, F. Mpembele, E. M. Miaka, M. Boelaert, M. J. Lehane, S. J. Torr, M. C. Stanton

This study evaluates the impact of Tiny Targets on tsetse fly populations in the Democratic Republic of Congo, finding an 85% reduction in fly catches following intervention.

bioRxiv · Apr 7, 2020Ecology