Author

D. Gray

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. Goodyear· 2 shared G. J. M. Cowan· 2 shared K. Miles· 2 shared M. Gray· 2 shared S. Breusch· 2 shared A. Basle· 1 shared A. Cartmell· 1 shared A. Glenwright· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

C. Goodyear

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A comprehensive analysis of rheumatoid arthritis B cells reveals the importance of CD11c+ve double-negative-2 B cells as the major synovial plasma cell precursor.

E. Wing, C. Sutherland, K. Miles, D. Gray, C. Goodyear, T. D. Otto, S. Breusch, G. J. M. Cowan, M. Gray

This study identifies CD11c+ve double-negative-2 B cells as the major synovial plasma cell precursor in rheumatoid arthritis using single-cell RNA and repertoire sequencing.

bioRxiv · Feb 15, 2023 · PreprintImmunology

Insights into glycan import by a prominent gut symbiont

D. Gray, J. White, A. Oluwole, P. Rath, A. Glenwright, A. Mazur, M. Zahn, A. Basle, C. Morland, S. Evans, A. Cartmell, C. V. Robinson, S. Hiller, N. Ranson, D. Bolam, B. van den Berg

This study characterizes the SusCD protein complex in Bacteroides thetaiotaomicron to elucidate its role in glycan uptake, revealing structural and functional insights into ligand binding and transport dynamics.

Nature Communications · Jan 4, 2021Peer-reviewedMicrobiology

Characterization of protease activity of Nsp3 from SARS-CoV-2 and its in vitro inhibition by nanobodies

L. Armstrong, S. M. Lange, V. de Cesare, S. P. Matthews, R. S. Nirujogi, I. Cole, A. Hope, F. Cunningham, R. Toth, R. Mukherjee, D. Bojkova, F. Gruber, D. Gray, P. G. Wyatt, J. Cinatl, , Y. Kulathu

This study characterizes Nsp3 protease activity from SARS-CoV-2 and identifies nanobodies that inhibit PLpro with nanomolar affinity.

bioRxiv · Dec 9, 2020Biochemistry

Rheumatoid arthritis patients express a skewed repertoire of polyclonal, hypomutated B-cell receptors

G. J. M. Cowan, K. Miles, L. Capitani, S. S. B. Giguere, H. Johnsson, C. Goodyear, I. B. McInnes, Scottish Early Rheumatoid Arthritis Inception cohort Investigators, S. Breusch, D. Gray, M. Gray

This study identifies that RA patients have a higher proportion of poorly mutated, polyclonal IgG+ve BCRs in peripheral blood and synovium, suggesting a role in autoimmune inflammation.

bioRxiv · Sep 18, 2019 · PreprintImmunology

Drug screening to identify compounds to act as co-therapies for the treatment of pathogenic Burkholderia

S. Barker, S. Harding, D. Gray, M. I. Richards, H. S. Atkins, N. Harmer

The paper identifies potential co-therapies for Burkholderia pseudomallei using a high-throughput screening assay with Burkholderia thailandensis, finding chloroxine as a promising candidate.

bioRxiv · Jul 8, 2019Microbiology

Demography and selection shape transcriptomic divergence in field crickets

T. Blankers, S. Vilaca, I. Waurick, D. Gray, M. Hennig, C. Mazzoni, F. Mayer, E. Berdan

The paper examines transcriptomic divergence in field crickets to disentangle the effects of demography and selection on genetic differentiation.

bioRxiv · Dec 20, 2017Evolutionary Biology